User:ProteinBoxBot/PBB Log Wiki 11-9-2007 A-4

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Log file for Protein Box Bot[edit]

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 03:33, 10 November 2007 (UTC)[edit]

Proteins without matches (14)[edit]

EIF4G2 SLC29A1 COPS6 PRPF8 RUVBL2
GJA5 DBI CYLD E2F3 GIPC1
CYB5A GJB6 FUT3 DLL1

Proteins with a High Potential Match (11)[edit]

PLCB1 FCGR3B CNTF CBX3 CBX1
FSHB AGA GHSR NLRP3 AMPH
FUCA1

Created (8)[edit]

EIF4G2 SLC29A1 COPS6 PRPF8 RUVBL2
GJA5 E2F3 CYB5A

Manual Inspection (Page not found) (17)[edit]

PLCB1 FCGR3B CNTF CBX3 CBX1
FSHB DBI CYLD GIPC1 AGA
GJB6 GHSR NLRP3 FUT3 AMPH
DLL1 FUCA1


Protein Status Grid - Date: 03:33, 10 November 2007 (UTC)[edit]

HUGO Symbol Action Summary Target page(s) WP Symbol Search
EIF4G2 Created Other Pages: Eukaryotic translation initiation factor 4 gamma (No Data); EIF4G2 (No Data); NAT1 (No Data); Nat1 (No Data); AAG1 (No Data); Aag1 (No Data); DAP5 (No Data); Dap5 (No Data); FLJ41344 (No Data); Flj41344 (No Data); P97 (No Data); [1]
PLCB1 Manual Inspection (Page not found) Other Pages: Phospholipase C (Protein Template); PLCB1 (No Data); PI-PLC (No Data); Pi-plc (No Data); FLJ45792 (No Data); Flj45792 (No Data); PLC-154 (No Data); Plc-154 (No Data); PLC-I (No Data); Plc-i (No Data); [2]
FCGR3B Manual Inspection (Page not found) Other Pages: Fc fragment of IgG (No Data); FCGR3B (No Data); CD16 (Protein Template); Cd16 (No Data); FCG3 (No Data); Fcg3 (No Data); FCGR3 (No Data); Fcgr3 (No Data); CD16b (Redirect -> CD16); Cd16b (No Data); [3]
SLC29A1 Created Other Pages: Solute carrier family 29 (No Data); SLC29A1 (No Data); ENT1 (No Data); Ent1 (No Data); MGC1465 (No Data); Mgc1465 (No Data); MGC3778 (No Data); Mgc3778 (No Data); [4]
CNTF Manual Inspection (Page not found) Other Pages: Ciliary neurotrophic factor (Protein Template); CNTF (Redirect -> Ciliary neurotrophic factor); HCNTF (No Data); Hcntf (No Data); [5]
CBX3 Manual Inspection (Page not found) Other Pages: Chromobox homolog 3 (Redirect -> heterochromatin protein 1); CBX3 (Redirect -> heterochromatin protein 1); HECH (No Data); Hech (No Data); HP1-GAMMA (No Data); Hp1-gamma (No Data); HP1Hs-gamma (No Data); Hp1hs-gamma (No Data); Heterochromatin protein 1 (Protein Template); [6]
CBX1 Manual Inspection (Page not found) Other Pages: Chromobox homolog 1 (Redirect -> heterochromatin protein 1); CBX1 (Redirect -> heterochromatin protein 1); CBX (DisAmbig); Cbx (Redirect -> CBX); HP1-BETA (No Data); Hp1-beta (No Data); HP1Hs-beta (No Data); Hp1hs-beta (No Data); M31 (DisAmbig); MOD1 (No Data); Mod1 (No Data); Heterochromatin protein 1 (Protein Template); [7]
FSHB Manual Inspection (Page not found) Other Pages: Follicle stimulating hormone (Redirect -> Follicle-stimulating hormone); FSHB (No Data); Follicle-stimulating hormone (Protein Template); [8]
COPS6 Created Other Pages: COP9 constitutive photomorphogenic homolog subunit 6 (No Data); COPS6 (No Data); MOV34-34KD (No Data); Mov34-34kd (No Data); [9]
PRPF8 Created Other Pages: PRP8 pre-mRNA processing factor 8 homolog (No Data); PRPF8 (No Data); PRP8 (No Data); Prp8 (No Data); HPRP8 (No Data); Hprp8 (No Data); PRPC8 (No Data); Prpc8 (No Data); RP13 (No Data); Rp13 (No Data); [10]
RUVBL2 Created Other Pages: RuvB-like 2 (No Data); RUVBL2 (No Data); CGI-46 (No Data); Cgi-46 (No Data); ECP51 (No Data); Ecp51 (No Data); RVB2 (No Data); Rvb2 (No Data); TIP48 (No Data); Tip48 (No Data); TIP49B (No Data); Tip49b (No Data); [11]
GJA5 Created Other Pages: Gap junction protein (No Data); GJA5 (No Data); CX40 (No Data); Cx40 (No Data); MGC11185 (No Data); Mgc11185 (No Data); [12]
DBI Manual Inspection (Page not found) Other Pages: Diazepam binding inhibitor (No Data); DBI (DisAmbig); ACBP (No Data); Acbp (No Data); ACBD1 (No Data); Acbd1 (No Data); CCK-RP (No Data); Cck-rp (No Data); EP (Redirect -> Extended play); Ep (Redirect -> Extended play); MGC70414 (No Data); Mgc70414 (No Data); Extended play (Unknown Data); [13]
CYLD Manual Inspection (Page not found) Other Pages: Cylindromatosis (No Data); CYLD (Redirect -> Chapleau Airport); CDMT (No Data); Cdmt (No Data); CYLD1 (No Data); Cyld1 (No Data); CYLDI (No Data); Cyldi (No Data); EAC (DisAmbig); Eac (Redirect -> EAC); FLJ20180 (No Data); Flj20180 (No Data); FLJ31664 (No Data); Flj31664 (No Data); HSPC057 (No Data); Hspc057 (No Data); KIAA0849 (No Data); Kiaa0849 (No Data); USPL2 (No Data); Uspl2 (No Data); Chapleau Airport (Unknown Data); [14]
E2F3 Created Other Pages: E2F transcription factor 3 (No Data); E2F3 (No Data); DKFZp686C18211 (No Data); Dkfzp686c18211 (No Data); E2F-3 (No Data); E2f-3 (No Data); KIAA0075 (No Data); Kiaa0075 (No Data); MGC104598 (No Data); Mgc104598 (No Data); [15]
GIPC1 Manual Inspection (Page not found) Other Pages: GIPC PDZ domain containing family (No Data); GIPC1 (No Data); C19orf3 (No Data); GIPC (No Data); Gipc (No Data); GLUT1CBP (No Data); Glut1cbp (No Data); Hs.6454 (No Data); IIP-1 (No Data); Iip-1 (No Data); MGC15889 (No Data); Mgc15889 (No Data); MGC3774 (No Data); Mgc3774 (No Data); NIP (No Data); Nip (DisAmbig); RGS19IP1 (No Data); Rgs19ip1 (No Data); SEMCAP (No Data); Semcap (No Data); SYNECTIIN (No Data); Synectiin (No Data); TIP-2 (No Data); Tip-2 (No Data); [16]
AGA Manual Inspection (Page not found) Other Pages: Aspartylglucosaminidase (Protein Template); AGA (DisAmbig); AGU (DisAmbig); Agu (Redirect -> AGU); ASRG (Redirect -> Anti-Spam Research Group); Asrg (No Data); GA (DisAmbig); Ga (Redirect -> GA); Anti-Spam Research Group (Unknown Data); [17]
CYB5A Created Other Pages: Cytochrome b5 type A (No Data); CYB5A (No Data); CYB5 (No Data); Cyb5 (No Data); MCB5 (No Data); Mcb5 (No Data); [18]
GJB6 Manual Inspection (Page not found) Other Pages: Gap junction protein (No Data); GJB6 (No Data); HED (No Data); Hed (Unknown Data); DFNA3 (No Data); Dfna3 (No Data); CX30 (No Data); Cx30 (No Data); ED2 (No Data); Ed2 (No Data); EDH (Redirect -> Error Detection and Handling); Edh (Redirect -> Eth); Error Detection and Handling (Unknown Data); Eth (Unknown Data); [19]
GHSR Manual Inspection (Page not found) Other Pages: Growth hormone secretagogue receptor (Protein Template); GHSR (No Data); [20]
NLRP3 Manual Inspection (Page not found) Other Pages: NLR family (No Data); NLRP3 (No Data); AVP (DisAmbig); Avp (Redirect -> AVP); AGTAVPRL (No Data); Agtavprl (No Data); AII (Redirect -> Agence de l'innovation industrielle); Aii (Redirect -> Agence de l'innovation industrielle); C1orf7 (No Data); CIAS1 (Protein Template); Cias1 (No Data); CLR1.1 (No Data); Clr1.1 (No Data); FCAS (Redirect -> Fixed Content Aware Storage); Fcas (No Data); FCU (No Data); Fcu (No Data); MWS (DisAmbig); Mws (No Data); NALP3 (No Data); Nalp3 (No Data); PYPAF1 (No Data); Pypaf1 (No Data); Agence de l'innovation industrielle (Unknown Data); Fixed Content Aware Storage (Unknown Data); [21]
FUT3 Manual Inspection (Page not found) Other Pages: Fucosyltransferase 3 (No Data); FUT3 (No Data); CD174 (No Data); Cd174 (No Data); LE (DisAmbig); Le (Redirect -> LE); Les (No Data); MGC131739 (No Data); Mgc131739 (No Data); [22]
AMPH Manual Inspection (Page not found) Other Pages: Amphiphysin (Protein Template); AMPH (No Data); AMPH1 (No Data); Amph1 (No Data); [23]
DLL1 Manual Inspection (Page not found) Other Pages: Delta-like 1 (No Data); DLL1 (No Data); DELTA1 (No Data); Delta1 (No Data); Delta (DisAmbig); [24]
FUCA1 Manual Inspection (Page not found) Other Pages: Fucosidase (Protein Template); FUCA1 (No Data); [25]

Vebose Log - Date: 03:33, 10 November 2007 (UTC)[edit]

AGA[edit]

  • INFO: Beginning work on AGA... {November 9, 2007 5:49:19 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein AGA image.jpg {November 9, 2007 5:50:46 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:51:43 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_AGA_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1apy.
 | PDB = {{PDB2|1apy}}, {{PDB2|1apz}}
 | Name = Aspartylglucosaminidase
 | HGNCid = 318
 | Symbol = AGA
 | AltSymbols =; AGU; ASRG; GA
 | OMIM = 208400
 | ECnumber =  
 | Homologene = 13
 | MGIid = 104873
 | GeneAtlas_image1 = PBB_GE_AGA_204333_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_AGA_204332_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_AGA_216064_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003948 |text = N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} 
 | Process = {{GNF_GO|id=GO:0006517 |text = protein deglycosylation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 175
    | Hs_Ensembl = ENSG00000038002
    | Hs_RefseqProtein = NP_000018
    | Hs_RefseqmRNA = NM_000027
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 178588918
    | Hs_GenLoc_end = 178600585
    | Hs_Uniprot = P20933
    | Mm_EntrezGene = 11593
    | Mm_Ensembl = ENSMUSG00000031521
    | Mm_RefseqmRNA = NM_001005847
    | Mm_RefseqProtein = NP_001005847
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 55010424
    | Mm_GenLoc_end = 55022120
    | Mm_Uniprot = Q64191
  }}
}}
'''Aspartylglucosaminidase''', also known as '''AGA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins.  The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.<ref>{{cite web | title = Entrez Gene: AGA aspartylglucosaminidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=175| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ikonen E, Peltonen L |title=Mutations causing aspartylglucosaminuria (AGU): a lysosomal accumulation disease. |journal=Hum. Mutat. |volume=1 |issue= 5 |pages= 361-5 |year= 1993 |pmid= 1301945 |doi= 10.1002/humu.1380010503 }}
*{{cite journal  | author=Mononen I, Fisher KJ, Kaartinen V, Aronson NN |title=Aspartylglycosaminuria: protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation. |journal=FASEB J. |volume=7 |issue= 13 |pages= 1247-56 |year= 1993 |pmid= 8405810 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

AMPH[edit]

  • INFO: Beginning work on AMPH... {November 9, 2007 5:51:43 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:52:13 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)
 | HGNCid = 471
 | Symbol = AMPH
 | AltSymbols =; AMPH1
 | OMIM = 600418
 | ECnumber =  
 | Homologene = 36072
 | MGIid = 103574
 | GeneAtlas_image1 = PBB_GE_AMPH_205257_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} 
 | Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 273
    | Hs_Ensembl = ENSG00000078053
    | Hs_RefseqProtein = NP_001626
    | Hs_RefseqmRNA = NM_001635
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 38389832
    | Hs_GenLoc_end = 38637545
    | Hs_Uniprot = P49418
    | Mm_EntrezGene = 218038
    | Mm_Ensembl = ENSMUSG00000021314
    | Mm_RefseqmRNA = NM_175007
    | Mm_RefseqProtein = NP_778172
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 18955836
    | Mm_GenLoc_end = 19158380
    | Mm_Uniprot = Q80YA2
  }}
}}
'''Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)''', also known as '''AMPH''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: AMPH amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=273| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

CBX1[edit]

  • INFO: Beginning work on CBX1... {November 9, 2007 7:20:04 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CBX1 image.jpg {November 9, 2007 7:20:38 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:20:58 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CBX1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ap0.
 | PDB = {{PDB2|1ap0}}, {{PDB2|1dz1}}, {{PDB2|1guw}}, {{PDB2|1s4z}}, {{PDB2|2fmm}}
 | Name = Chromobox homolog 1 (HP1 beta homolog Drosophila )
 | HGNCid = 1551
 | Symbol = CBX1
 | AltSymbols =; CBX; HP1-BETA; HP1Hs-beta; M31; MOD1
 | OMIM = 604511
 | ECnumber =  
 | Homologene = 38228
 | MGIid = 105369
 | GeneAtlas_image1 = PBB_GE_CBX1_201518_at_tn.png
 | Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0001939 |text = female pronucleus}} {{GNF_GO|id=GO:0001940 |text = male pronucleus}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005701 |text = polytene chromosome chromocenter}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}} {{GNF_GO|id=GO:0005721 |text = centric heterochromatin}} 
 | Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10951
    | Hs_Ensembl = ENSG00000108468
    | Hs_RefseqProtein = NP_006798
    | Hs_RefseqmRNA = NM_006807
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43502414
    | Hs_GenLoc_end = 43533806
    | Hs_Uniprot = P83916
    | Mm_EntrezGene = 12412
    | Mm_Ensembl = ENSMUSG00000018666
    | Mm_RefseqmRNA = XM_990275
    | Mm_RefseqProtein = XP_995369
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96605249
    | Mm_GenLoc_end = 96624730
    | Mm_Uniprot = Q7TPM0
  }}
}}
'''Chromobox homolog 1 (HP1 beta homolog Drosophila )''', also known as '''CBX1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10951| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

CBX3[edit]

  • INFO: Beginning work on CBX3... {November 9, 2007 7:21:56 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:22:33 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Chromobox homolog 3 (HP1 gamma homolog, Drosophila)
 | HGNCid = 1553
 | Symbol = CBX3
 | AltSymbols =; HECH; HP1-GAMMA; HP1Hs-gamma
 | OMIM = 604477
 | ECnumber =  
 | Homologene = 40583
 | MGIid = 108515
 | GeneAtlas_image1 = PBB_GE_CBX3_200037_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11335
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_009207
    | Hs_RefseqmRNA = NM_007276
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 12417
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_001037798
    | Mm_RefseqProtein = NP_001032887
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Chromobox homolog 3 (HP1 gamma homolog, Drosophila)''', also known as '''CBX3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.<ref>{{cite web | title = Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11335| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

CNTF[edit]

  • INFO: Beginning work on CNTF... {November 9, 2007 5:52:13 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CNTF image.jpg {November 9, 2007 5:52:47 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:52:57 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CNTF_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cnt.
 | PDB = {{PDB2|1cnt}}
 | Name = Ciliary neurotrophic factor
 | HGNCid = 2169
 | Symbol = CNTF
 | AltSymbols =; HCNTF
 | OMIM = 118945
 | ECnumber =  
 | Homologene = 8288
 | MGIid = 88439
 | GeneAtlas_image1 = PBB_GE_CNTF_208597_at_tn.png
 | Function = {{GNF_GO|id=GO:0005127 |text = ciliary neurotrophic factor receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0040007 |text = growth}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1270
    | Hs_Ensembl = ENSG00000205003
    | Hs_RefseqProtein = NP_000605
    | Hs_RefseqmRNA = NM_000614
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 58146721
    | Hs_GenLoc_end = 58149778
    | Hs_Uniprot = P26441
    | Mm_EntrezGene = 12803
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_053007
    | Mm_RefseqProtein = NP_443733
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Ciliary neurotrophic factor''', also known as '''CNTF''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.<ref>{{cite web | title = Entrez Gene: CNTF ciliary neurotrophic factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1270| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Sendtner M, Carroll P, Holtmann B, ''et al.'' |title=Ciliary neurotrophic factor. |journal=J. Neurobiol. |volume=25 |issue= 11 |pages= 1436-53 |year= 1995 |pmid= 7852996 |doi= 10.1002/neu.480251110 }}
*{{cite journal  | author=Sleeman MW, Anderson KD, Lambert PD, ''et al.'' |title=The ciliary neurotrophic factor and its receptor, CNTFR alpha. |journal=Pharmaceutica acta Helvetiae |volume=74 |issue= 2-3 |pages= 265-72 |year= 2000 |pmid= 10812968 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

COPS6[edit]

  • INFO: Beginning work on COPS6... {November 9, 2007 7:20:58 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:21:48 PM PST}
  • CREATED: Created new protein page: COPS6 {November 9, 2007 7:21:56 PM PST}

CYB5A[edit]

  • INFO: Beginning work on CYB5A... {November 9, 2007 5:52:57 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CYB5A image.jpg {November 9, 2007 5:54:08 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 5:54:20 PM PST}
  • CREATED: Created new protein page: CYB5A {November 9, 2007 5:54:27 PM PST}

CYLD[edit]

  • INFO: Beginning work on CYLD... {November 9, 2007 5:54:27 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CYLD image.jpg {November 9, 2007 5:55:42 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 5:56:09 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CYLD_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ixd.
 | PDB = {{PDB2|1ixd}}, {{PDB2|1whl}}, {{PDB2|1whm}}
 | Name = Cylindromatosis (turban tumor syndrome)
 | HGNCid = 2584
 | Symbol = CYLD
 | AltSymbols =; CDMT; CYLD1; CYLDI; EAC; FLJ20180; FLJ31664; HSPC057; KIAA0849; USPL2
 | OMIM = 605018
 | ECnumber =  
 | Homologene = 9069
 | MGIid = 1921506
 | GeneAtlas_image1 = PBB_GE_CYLD_214272_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CYLD_221903_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_CYLD_221905_at_tn.png
 | Function = {{GNF_GO|id=GO:0003735 |text = structural constituent of ribosome}} {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005840 |text = ribosome}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} 
 | Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1540
    | Hs_Ensembl = ENSG00000083799
    | Hs_RefseqProtein = NP_001035814
    | Hs_RefseqmRNA = NM_001042355
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 49333486
    | Hs_GenLoc_end = 49390029
    | Hs_Uniprot = Q9NQC7
    | Mm_EntrezGene = 74256
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_173369
    | Mm_RefseqProtein = NP_775545
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Cylindromatosis (turban tumor syndrome)''', also known as '''CYLD''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: CYLD cylindromatosis (turban tumor syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1540| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Lian F, Cockerell CJ |title=Cutaneous appendage tumors: familial cylindromatosis and associated tumors update. |journal=Advances in dermatology |volume=21 |issue=  |pages= 217-34 |year= 2006 |pmid= 16350444 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

DBI[edit]

  • INFO: Beginning work on DBI... {November 9, 2007 5:56:09 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein DBI image.jpg {November 9, 2007 7:07:54 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:08:18 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_DBI_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aca.
 | PDB = {{PDB2|1aca}}, {{PDB2|1hb6}}, {{PDB2|1hb8}}, {{PDB2|1nti}}, {{PDB2|1nvl}}, {{PDB2|2abd}}, {{PDB2|2cb8}}, {{PDB2|2fj9}}
 | Name = Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
 | HGNCid = 2690
 | Symbol = DBI
 | AltSymbols =; ACBP; ACBD1; CCK-RP; EP; MGC70414
 | OMIM = 125950
 | ECnumber =  
 | Homologene = 39086
 | MGIid = 94865
 | GeneAtlas_image1 = PBB_GE_DBI_202428_x_at_tn.png
 | GeneAtlas_image2 = PBB_GE_DBI_209389_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_DBI_211070_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0000062 |text = acyl-CoA binding}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0030156 |text = benzodiazepine receptor binding}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006810 |text = transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1622
    | Hs_Ensembl = ENSG00000155368
    | Hs_RefseqProtein = NP_001073331
    | Hs_RefseqmRNA = NM_001079862
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 119841055
    | Hs_GenLoc_end = 119846586
    | Hs_Uniprot = P07108
    | Mm_EntrezGene = 13167
    | Mm_Ensembl = ENSMUSG00000026385
    | Mm_RefseqmRNA = NM_001037999
    | Mm_RefseqProtein = NP_001033088
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 121940826
    | Mm_GenLoc_end = 121948625
    | Mm_Uniprot = Q3ULV8
  }}
}}
'''Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)''', also known as '''DBI''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1622| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Papadopoulos V, Brown AS |title=Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1-6 |pages= 103-10 |year= 1995 |pmid= 7626442 |doi=  }}
*{{cite journal  | author=Costa E, Auta J, Guidotti A, ''et al.'' |title=The pharmacology of neurosteroidogenesis. |journal=J. Steroid Biochem. Mol. Biol. |volume=49 |issue= 4-6 |pages= 385-9 |year= 1994 |pmid= 8043504 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

DLL1[edit]

  • INFO: Beginning work on DLL1... {November 9, 2007 7:24:06 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:24:43 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Delta-like 1 (Drosophila)
 | HGNCid = 2908
 | Symbol = DLL1
 | AltSymbols =; DELTA1; Delta
 | OMIM = 606582
 | ECnumber =  
 | Homologene = 4104
 | MGIid = 104659
 | GeneAtlas_image1 = PBB_GE_DLL1_gnf1h00074_at_tn.png
 | Function = {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0031410 |text = cytoplasmic vesicle}} 
 | Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0001757 |text = somite specification}} {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0007386 |text = compartment specification}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0009912 |text = auditory receptor cell fate commitment}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045608 |text = negative regulation of auditory receptor cell differentiation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 28514
    | Hs_Ensembl = ENSG00000198719
    | Hs_RefseqProtein = NP_005609
    | Hs_RefseqmRNA = NM_005618
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 170433219
    | Hs_GenLoc_end = 170441486
    | Hs_Uniprot = O00548
    | Mm_EntrezGene = 13388
    | Mm_Ensembl = ENSMUSG00000014773
    | Mm_RefseqmRNA = NM_007865
    | Mm_RefseqProtein = NP_031891
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 15073094
    | Mm_GenLoc_end = 15080203
    | Mm_Uniprot = Q6PFV7
  }}
}}
'''Delta-like 1 (Drosophila)''', also known as '''DLL1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family.  It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.<ref>{{cite web | title = Entrez Gene: DLL1 delta-like 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Watt FM |title=The stem cell compartment in human interfollicular epidermis. |journal=J. Dermatol. Sci. |volume=28 |issue= 3 |pages= 173-80 |year= 2002 |pmid= 11912004 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

E2F3[edit]

  • INFO: Beginning work on E2F3... {November 9, 2007 7:08:18 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:08:54 PM PST}
  • CREATED: Created new protein page: E2F3 {November 9, 2007 7:09:04 PM PST}

EIF4G2[edit]

  • INFO: Beginning work on EIF4G2... {November 9, 2007 7:09:04 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:09:29 PM PST}
  • CREATED: Created new protein page: EIF4G2 {November 9, 2007 7:09:38 PM PST}

FCGR3B[edit]

  • INFO: Beginning work on FCGR3B... {November 9, 2007 7:10:49 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein FCGR3B image.jpg {November 9, 2007 7:11:42 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:11:58 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_FCGR3B_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e4j.
 | PDB = {{PDB2|1e4j}}, {{PDB2|1e4k}}, {{PDB2|1fnl}}, {{PDB2|1iis}}, {{PDB2|1iix}}, {{PDB2|1t83}}, {{PDB2|1t89}}
 | Name = Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
 | HGNCid = 3620
 | Symbol = FCGR3B
 | AltSymbols =; CD16; FCG3; FCGR3; CD16b
 | OMIM = 610665
 | ECnumber =  
 | Homologene = 88333
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_FCGR3B_204007_at_tn.png
 | GeneAtlas_image2 = PBB_GE_FCGR3B_204006_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0019864 |text = IgG binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}} 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006955 |text = immune response}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2215
    | Hs_Ensembl = ENSG00000162747
    | Hs_RefseqProtein = NP_000561
    | Hs_RefseqmRNA = NM_000570
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 159859610
    | Hs_GenLoc_end = 159867620
    | Hs_Uniprot = O75015
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Fc fragment of IgG, low affinity IIIb, receptor (CD16b)''', also known as '''FCGR3B''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

FSHB[edit]

  • INFO: Beginning work on FSHB... {November 9, 2007 7:11:58 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein FSHB image.jpg {November 9, 2007 7:12:34 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:12:44 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_FSHB_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fl7.
 | PDB = {{PDB2|1fl7}}, {{PDB2|1xwd}}
 | Name = Follicle stimulating hormone, beta polypeptide
 | HGNCid = 3964
 | Symbol = FSHB
 | AltSymbols =; 
 | OMIM = 136530
 | ECnumber =  
 | Homologene = 430
 | MGIid = 95582
 | GeneAtlas_image1 = PBB_GE_FSHB_214489_at_tn.png
 | Function = {{GNF_GO|id=GO:0016913 |text = follicle-stimulating hormone activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} 
 | Process = {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2488
    | Hs_Ensembl = ENSG00000131808
    | Hs_RefseqProtein = NP_000501
    | Hs_RefseqmRNA = NM_000510
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 30209139
    | Hs_GenLoc_end = 30213384
    | Hs_Uniprot = P01225
    | Mm_EntrezGene = 14308
    | Mm_Ensembl = ENSMUSG00000027120
    | Mm_RefseqmRNA = NM_008045
    | Mm_RefseqProtein = NP_032071
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 106856973
    | Mm_GenLoc_end = 106860490
    | Mm_Uniprot = Q60687
  }}
}}
'''Follicle stimulating hormone, beta polypeptide''', also known as '''FSHB''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.<ref>{{cite web | title = Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2488| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Barrios-De-Tomasi J, Timossi C, Merchant H, ''et al.'' |title=Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. |journal=Mol. Cell. Endocrinol. |volume=186 |issue= 2 |pages= 189-98 |year= 2002 |pmid= 11900895 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

FUCA1[edit]

  • INFO: Beginning work on FUCA1... {November 9, 2007 7:12:44 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:13:13 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Fucosidase, alpha-L- 1, tissue
 | HGNCid = 4006
 | Symbol = FUCA1
 | AltSymbols =; 
 | OMIM = 230000
 | ECnumber =  
 | Homologene = 20078
 | MGIid = 95593
 | GeneAtlas_image1 = PBB_GE_FUCA1_202838_at_tn.png
 | Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004560 |text = alpha-L-fucosidase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0043169 |text = cation binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} 
 | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006027 |text = glycosaminoglycan catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2517
    | Hs_Ensembl = ENSG00000179163
    | Hs_RefseqProtein = NP_000138
    | Hs_RefseqmRNA = NM_000147
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 24044154
    | Hs_GenLoc_end = 24067371
    | Hs_Uniprot = P04066
    | Mm_EntrezGene = 71665
    | Mm_Ensembl = ENSMUSG00000028673
    | Mm_RefseqmRNA = NM_024243
    | Mm_RefseqProtein = NP_077205
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 135192833
    | Mm_GenLoc_end = 135212389
    | Mm_Uniprot = Q3TCW3
  }}
}}
'''Fucosidase, alpha-L- 1, tissue''', also known as '''FUCA1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form; and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: FUCA1 fucosidase, alpha-L- 1, tissue| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2517| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Willems PJ, Gatti R, Darby JK, ''et al.'' |title=Fucosidosis revisited: a review of 77 patients. |journal=Am. J. Med. Genet. |volume=38 |issue= 1 |pages= 111-31 |year= 1991 |pmid= 2012122 |doi= 10.1002/ajmg.1320380125 }}
*{{cite journal  | author=Willems PJ, Seo HC, Coucke P, ''et al.'' |title=Spectrum of mutations in fucosidosis. |journal=Eur. J. Hum. Genet. |volume=7 |issue= 1 |pages= 60-7 |year= 1999 |pmid= 10094192 |doi= 10.1038/sj.ejhg.5200272 }}
}}
{{refend}}

{{protein-stub}}
 

FUT3[edit]

  • INFO: Beginning work on FUT3... {November 9, 2007 7:13:13 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:14:46 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
 | HGNCid = 4014
 | Symbol = FUT3
 | AltSymbols =; CD174; LE; Les; MGC131739
 | OMIM = 111100
 | ECnumber =  
 | Homologene = 55438
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_FUT3_214088_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_FUT3_210398_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_FUT3_211882_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0017060 |text = 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2525
    | Hs_Ensembl = ENSG00000171124
    | Hs_RefseqProtein = NP_000140
    | Hs_RefseqmRNA = NM_000149
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 5793902
    | Hs_GenLoc_end = 5802482
    | Hs_Uniprot = P21217
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)''', also known as '''FUT3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.<ref>{{cite web | title = Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2525| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

GHSR[edit]

  • INFO: Beginning work on GHSR... {November 9, 2007 7:14:46 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:15:21 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Growth hormone secretagogue receptor
 | HGNCid = 4267
 | Symbol = GHSR
 | AltSymbols =; 
 | OMIM = 601898
 | ECnumber =  
 | Homologene = 57161
 | MGIid = 2441906
 | GeneAtlas_image1 = PBB_GE_GHSR_221360_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001616 |text = growth hormone secretagogue receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016520 |text = growth hormone-releasing hormone receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008343 |text = adult feeding behavior}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}} {{GNF_GO|id=GO:0030252 |text = growth hormone secretion}} {{GNF_GO|id=GO:0032100 |text = positive regulation of appetite}} {{GNF_GO|id=GO:0040018 |text = positive regulation of body size}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2693
    | Hs_Ensembl = ENSG00000121853
    | Hs_RefseqProtein = NP_004113
    | Hs_RefseqmRNA = NM_004122
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 173645645
    | Hs_GenLoc_end = 173648897
    | Hs_Uniprot = Q92847
    | Mm_EntrezGene = 208188
    | Mm_Ensembl = ENSMUSG00000051136
    | Mm_RefseqmRNA = NM_177330
    | Mm_RefseqProtein = NP_796304
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 27562424
    | Mm_GenLoc_end = 27569083
    | Mm_Uniprot = Q0VBE5
  }}
}}
'''Growth hormone secretagogue receptor''', also known as '''GHSR''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a.<ref>{{cite web | title = Entrez Gene: GHSR growth hormone secretagogue receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2693| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Smith RG, Leonard R, Bailey AR, ''et al.'' |title=Growth hormone secretagogue receptor family members and ligands. |journal=Endocrine |volume=14 |issue= 1 |pages= 9-14 |year= 2001 |pmid= 11322507 |doi=  }}
*{{cite journal  | author=Petersenn S |title=Structure and regulation of the growth hormone secretagogue receptor. |journal=Minerva Endocrinol. |volume=27 |issue= 4 |pages= 243-56 |year= 2003 |pmid= 12511847 |doi=  }}
*{{cite journal  | author=Holst B, Schwartz TW |title=Ghrelin receptor mutations--too little height and too much hunger. |journal=J. Clin. Invest. |volume=116 |issue= 3 |pages= 637-41 |year= 2006 |pmid= 16511600 |doi= 10.1172/JCI27999 }}
*{{cite journal  | author=Nogueiras R, Perez-Tilve D, Wortley KE, Tschöp M |title=Growth hormone secretagogue (ghrelin-) receptors--a complex drug target for the regulation of body weight. |journal=CNS & neurological disorders drug targets |volume=5 |issue= 3 |pages= 335-43 |year= 2006 |pmid= 16787234 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

GIPC1[edit]

  • INFO: Beginning work on GIPC1... {November 9, 2007 7:17:34 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:18:33 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = GIPC PDZ domain containing family, member 1
 | HGNCid = 1226
 | Symbol = GIPC1
 | AltSymbols =; C19orf3; GIPC; GLUT1CBP; Hs.6454; IIP-1; MGC15889; MGC3774; NIP; RGS19IP1; SEMCAP; SYNECTIIN; TIP-2
 | OMIM = 605072
 | ECnumber =  
 | Homologene = 21167
 | MGIid = 1926252
 | GeneAtlas_image1 = PBB_GE_GIPC1_207525_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005938 |text = cell cortex}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0012506 |text = vesicle membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}} {{GNF_GO|id=GO:0043198 |text = dendritic shaft}} 
 | Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0014047 |text = glutamate secretion}} {{GNF_GO|id=GO:0048167 |text = regulation of synaptic plasticity}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10755
    | Hs_Ensembl = ENSG00000123159
    | Hs_RefseqProtein = NP_005707
    | Hs_RefseqmRNA = NM_005716
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 14449572
    | Hs_GenLoc_end = 14467944
    | Hs_Uniprot = O14908
    | Mm_EntrezGene = 67903
    | Mm_Ensembl = ENSMUSG00000019433
    | Mm_RefseqmRNA = NM_018771
    | Mm_RefseqProtein = NP_061241
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 86542783
    | Mm_GenLoc_end = 86554894
    | Mm_Uniprot = Q9Z0G0
  }}
}}
'''GIPC PDZ domain containing family, member 1''', also known as '''GIPC1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Katoh M |title=GIPC gene family (Review). |journal=Int. J. Mol. Med. |volume=9 |issue= 6 |pages= 585-9 |year= 2002 |pmid= 12011974 |doi=  }}
*{{cite journal  | author=Hasson T |title=Myosin VI: two distinct roles in endocytosis. |journal=J. Cell. Sci. |volume=116 |issue= Pt 17 |pages= 3453-61 |year= 2004 |pmid= 12893809 |doi= 10.1242/jcs.00669 }}
}}
{{refend}}

{{protein-stub}}
 

GJA5[edit]

  • INFO: Beginning work on GJA5... {November 9, 2007 7:15:21 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:16:00 PM PST}
  • CREATED: Created new protein page: GJA5 {November 9, 2007 7:16:08 PM PST}

GJB6[edit]

  • INFO: Beginning work on GJB6... {November 9, 2007 7:18:33 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:19:03 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Gap junction protein, beta 6
 | HGNCid = 4288
 | Symbol = GJB6
 | AltSymbols =; HED; DFNA3; CX30; ED2; EDH
 | OMIM = 604418
 | ECnumber =  
 | Homologene = 4936
 | MGIid = 107588
 | Function = {{GNF_GO|id=GO:0003823 |text = antigen binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015285 |text = gap-junction channel activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005922 |text = connexon complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0042471 |text = ear morphogenesis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10804
    | Hs_Ensembl = ENSG00000121742
    | Hs_RefseqProtein = NP_006774
    | Hs_RefseqmRNA = NM_006783
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 19694103
    | Hs_GenLoc_end = 19704366
    | Hs_Uniprot = O95452
    | Mm_EntrezGene = 14623
    | Mm_Ensembl = ENSMUSG00000040055
    | Mm_RefseqmRNA = NM_001010937
    | Mm_RefseqProtein = NP_001010937
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 56077413
    | Mm_GenLoc_end = 56087687
    | Mm_Uniprot = Q3URC5
  }}
}}
'''Gap junction protein, beta 6''', also known as '''GJB6''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The connexin gene family codes for the protein subunits of gap junction channels that mediate direct diffusion of ions and metabolites between the cytoplasm of adjacent cells. Connexins span the plasma membrane 4 times, with amino- and carboxy-terminal regions facing the cytoplasm. Connexin genes are expressed in a cell type-specific manner with overlapping specificity. The gap junction channels have unique properties depending on the type of connexins constituting the channel.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GJB6 gap junction protein, beta 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10804| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

NLRP3[edit]

  • INFO: Beginning work on NLRP3... {November 9, 2007 7:24:43 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:26:01 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = NLR family, pyrin domain containing 3
 | HGNCid = 16400
 | Symbol = NLRP3
 | AltSymbols =; AVP; AGTAVPRL; AII; AII/AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1
 | OMIM = 606416
 | ECnumber =  
 | Homologene = 3600
 | MGIid = 2653833
 | GeneAtlas_image1 = PBB_GE_NLRP3_216015_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_NLRP3_207075_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042834 |text = peptidoglycan binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0009595 |text = detection of biotic stimulus}} {{GNF_GO|id=GO:0032088 |text = inhibition of NF-kappaB transcription factor}} {{GNF_GO|id=GO:0042347 |text = negative regulation of NF-kappaB import into nucleus}} {{GNF_GO|id=GO:0043280 |text = positive regulation of caspase activity}} {{GNF_GO|id=GO:0050718 |text = positive regulation of interleukin-1 beta secretion}} {{GNF_GO|id=GO:0051259 |text = protein oligomerization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114548
    | Hs_Ensembl = ENSG00000162711
    | Hs_RefseqProtein = NP_001073289
    | Hs_RefseqmRNA = NM_001079821
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 245647974
    | Hs_GenLoc_end = 245679033
    | Hs_Uniprot = Q96P20
    | Mm_EntrezGene = 216799
    | Mm_Ensembl = ENSMUSG00000032691
    | Mm_RefseqmRNA = XM_001003938
    | Mm_RefseqProtein = XP_001003938
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 59357780
    | Mm_GenLoc_end = 59383151
    | Mm_Uniprot = Q1JQ87
  }}
}}
'''NLR family, pyrin domain containing 3''', also known as '''NLRP3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with apoptosis-associated speck-like protein containing a CARD. Proteins which contain the caspase recruitment domain, CARD, have been shown to be involved in inflammation and immune response. This protein may function as an activator of NF-kappaB signaling. The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutations in this gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: NLRP3 NLR family, pyrin domain containing 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114548| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Tschopp J, Martinon F, Burns K |title=NALPs: a novel protein family involved in inflammation. |journal=Nat. Rev. Mol. Cell Biol. |volume=4 |issue= 2 |pages= 95-104 |year= 2003 |pmid= 12563287 |doi= 10.1038/nrm1019 }}
*{{cite journal  | author=Martinon F, Tschopp J |title=NLRs join TLRs as innate sensors of pathogens. |journal=Trends Immunol. |volume=26 |issue= 8 |pages= 447-54 |year= 2006 |pmid= 15967716 |doi= 10.1016/j.it.2005.06.004 }}
}}
{{refend}}

{{protein-stub}}
 

PLCB1[edit]

  • INFO: Beginning work on PLCB1... {November 9, 2007 7:22:33 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 7:24:06 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Phospholipase C, beta 1 (phosphoinositide-specific)
 | HGNCid = 15917
 | Symbol = PLCB1
 | AltSymbols =; PI-PLC; FLJ45792; PLC-154; PLC-I
 | OMIM = 607120
 | ECnumber =  
 | Homologene = 22876
 | MGIid = 97613
 | GeneAtlas_image1 = PBB_GE_PLCB1_211925_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PLCB1_213222_at_tn.png
 | GeneAtlas_image3 = PBB_GE_PLCB1_215687_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23236
    | Hs_Ensembl = ENSG00000182621
    | Hs_RefseqProtein = NP_056007
    | Hs_RefseqmRNA = NM_015192
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 8060908
    | Hs_GenLoc_end = 8813547
    | Hs_Uniprot = Q9NQ66
    | Mm_EntrezGene = 18795
    | Mm_Ensembl = ENSMUSG00000051177
    | Mm_RefseqmRNA = NM_019677
    | Mm_RefseqProtein = NP_062651
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 134477974
    | Mm_GenLoc_end = 135163721
    | Mm_Uniprot = Q2M4J2
  }}
}}
'''Phospholipase C, beta 1 (phosphoinositide-specific)''', also known as '''PLCB1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23236| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Martelli AM, Fiume R, Faenza I, ''et al.'' |title=Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1251-60 |year= 2006 |pmid= 16136505 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

PRPF8[edit]

  • INFO: Beginning work on PRPF8... {November 9, 2007 7:16:08 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:17:27 PM PST}
  • CREATED: Created new protein page: PRPF8 {November 9, 2007 7:17:34 PM PST}

RUVBL2[edit]

  • INFO: Beginning work on RUVBL2... {November 9, 2007 7:19:03 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein RUVBL2 image.jpg {November 9, 2007 7:19:38 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:19:57 PM PST}
  • CREATED: Created new protein page: RUVBL2 {November 9, 2007 7:20:04 PM PST}

SLC29A1[edit]

  • INFO: Beginning work on SLC29A1... {November 9, 2007 7:09:39 PM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 7:10:40 PM PST}
  • CREATED: Created new protein page: SLC29A1 {November 9, 2007 7:10:48 PM PST}

end log.