My interests include pharmacology, chemical engineering, chemistry and drug abuse. I have a keen interest in indexing information to allow interested parties to quickly learn more about a subject while also allowing experts to expand their understanding and support their claims.
I have created a number of pages, particularly regarding reagent tests for drug identification and TLC development.
- Dille–Koppanyi reagent
- Ehrlich's reagent
- Froehde reagent
- Mecke reagent
- Mandelin reagent
- Simon's reagent
- Duquenois-Levine reagent
- Zwikker reagent
- Vacuum bazooka
I created most of the content for 5-(2-Aminopropyl)indole and have contributed considerably to the entries for blood substitutes, tert-Amyl alcohol methoxetamine, alcohol toxicity, oxygen scavengers, 2C-B, emylcamate, aMT and desoxypipradrol.
I have thoroughly overhauled a number of articles on air separation techniques including gas separation, oxygen concentrators, pressure swing adsorption, membrane gas separation and portable oxygen concentrators.
- Zipeprol is a centrally acting cough suppressant developed in France in the 1970s. Zipeprol acts as a local anaesthetic and has mucolytic, antihistamine and anticholinergic properties.. It has been misused in Korea, mainly for the hallucinations it produces. Such use has become an issue due to the seizures and various neurological side effects it causes at high dosages.
- Nitromethaqualone is more 10x potent than methaqualone could replacing the nitro with another EWG retain the potency while losing the toxicity? Cloroqualone is less potent than methaqualone, so what would an EDG like -OR do in place of chlorine?Discussion:
- MTEP and MPEP. MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant and anxiolytic effects but with either similar or higher efficacy depending on the test used.
- 2-Phenyl-3,6-dimethylmorpholine "wqs one of the battery of compounds fed to rats during my short bout of academia (I'll try and find my notes, but it's from 20-odd years ago & the spare room is full of crap that needs to be sorted); the reason it stuck in my mind, other than not being a controlled substance, is that the phenmetrazine series are quite a simple synth from phenylpropanolamine (no synth details for obvious reasons). The 3,5 dimethyl compound behaves more like an N-isopropyl substituted sympathetic agent (more peripheral effects such as pounding heart, dry mouth, sweating etc) and is possibly stearically hindered about the amine function due to increased rigidity conferred by the morpholine ring (expressed as only having a fraction of the locomotor stimulant/appetite supressant activity of the 3,6 or parent phenmetrazine)"
- Etoxadrol is a dissociative not covered by the UK's catch all clause
- GYKI-52895 A benzo-1,2-diazepine which acts as a DRI. An MDMA pharmacophore(?) can be seen.
Kim, H. W.; Greenburg, A. G. (2004). "Artificial Oxygen Carriers as Red Blood Cell Substitutes: A Selected Review and Current Status". Artificial Organs 28 (9): 813–828. doi:10.1111/j.1525-1594.2004.07345.x. PMID 15320945.
Vasodilation caused by ibuprofen
Ibuprofen has been shown to dilate arteries in rats with coronary vasodilation, equal to that caused by hypoxia at 140 µg/mL. Typical human dosages of 400mg result in a concentration of 20-60 µg/mL.
- Patent US 3718650, Mauvernay,RY, "New Derivatives of Substituted Piperazines", issued 1973-02-27
- Rispat, G.; Burgi, H.; Cosnier, D.; Duchêne-Marullaz, P.; Streichenberger, G. (1976). "General pharmacological properties of a new non-opiate antitussive: Zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity". Arzneimittel-Forschung 26 (4): 523–530. PMID 8057.
- Chung, H.; Park, M.; Hahn, E.; Choi, H.; Choi, H.; Lim, M. (2004). "Recent Trends of Drug Abuse and Drug-Associated Deaths in Korea". Annals of the New York Academy of Sciences 1025: 458–464. doi:10.1196/annals.1316.056. PMID 15542749.
- MurphyClox. ""methylmethaqualone"".
- fastandbulbous. "Stimulants of the Future".
- Apstein, C. S.; Vogel, W. M. (1982). "Coronary arterial vasodilator effect of ibuprofen". The Journal of pharmacology and experimental therapeutics 220 (1): 167–71. PMID 7053413.
- "Oral NSAID pharmacokinetics".