User talk:Boghog

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Thank you for being one of Wikipedia's top medical contributors![edit]

please help translate this message into the local language
Wiki Project Med Foundation logo.svg The Cure Award
In 2013 you were one of the top 300 medical editors across any language of Wikipedia. Thank you so much for helping bring free, complete, accurate, up-to-date medical information to the public. We really appreciate you and the vital work you do!

We are wondering about the educational background of our top medical editors. Would you please complete a quick 5-question survey? (please only fill this out if you received the award)

Thanks again :) --Ocaasi, Doc James and the team at Wiki Project Med Foundation

Deleting the message is fine[edit]

Your Talk page is yours to do with as you please. Message was intended just for you, in any case. Sad that you can see only nonsense, and nothing worth your consideration, but that is the state of things. Cheers. Le Prof

In reply to your talk my page also appearing immediately above[edit]

I have no clue as to who Flyer22 is in relation to the question of highlighting Talk text to make minority voices clearer, or what "refactoring" or "archiving" are, and what they have to do with highlighting. Here, brevity is your enemy; I am not chasing possible meanings down for you. This you need to clarify, significantly, to simply be understood. As for Padillah's statement, I have asked him to make clear what he wants, and when he does, I will act. As for your "protest", you can assuredly speak to what I do with your comments, but—as far as I see in the WPs, and as far as I have been counseled—not about what I do with other others' comments. I have highlighted none of your comments. I have queried all others, and will respond to their requests. It is, I understand, up to them, individually. (There is no overriding, firm policy, whatever you might think; this is what I am told.) So for now, I will await Padillah et al's replies, and yours if you care to say more. (But no action taken until.) Cheers. Le Prof

Need to update template:Amphetamine pharmacodynamics...[edit]

Hey Boghog. I noticed in the recently updated KEGG pathway as well as in a recently published paper that presynaptic CaMKIIα signaling plays a role in amphetamine-induced dopamine efflux. Unfortunately, the mechanism of this isn't published because the KEGG and the DAT researchers working on this somehow have never heard of trace amine-associated receptors...

After reading all the papers, it seems intuitive to me how this works, but I wanted to run these steps by you before I update the diagram:

  1. Since TAAR1 is Gq-coupled, its activation causes an influx of calcium via IP3R in the presynaptic neuron (as noted in PMID 16831861 and IUPHAR's TAAR1 page).
  2. From this point, the intermediate pathway steps between the calcium channel and CaMKIIα are analogous to the pathway in template:Psychostimulant addiction
  3. CaMKIIα-dependent DAT phosphorylation occurs and results in dopamine efflux/reverse transport

In a nutshell, I'd basically be drawing the following connections: TAAR1 → IP3R → CaM → CaMKIIα → DAT (I'd need to draw IP3R). That said, is there anything missing, or does that sound right?Seppi333 (Insert  | Maintained) 02:55, 12 November 2014 (UTC)

I can't even find a review that includes amphetamine and CAMKII, so I'm just going to ignore this until someone decides to write one. The only primary source I found that mentioned both TAAR1-mediated PKC and CAMKII as mechanisms of amphetamine efflux didn't draw the conclusion I jumped to either, so I probably shouldn't do this anyway. I still think that a bit odd how there isn't a paper covering all three kinases yet. Seppi333 (Insert  | Maintained) 08:15, 8 December 2014 (UTC)
@Seppi333: Sorry for not responding sooner. I did take a look at this a couple of weeks ago and could not find any sources that made the connection either. While your reasoning appears to be sound, unfortunately we cannot include the connection without a reliable source to support the connection, otherwise it become OR. Cheers. Boghog (talk) 21:23, 8 December 2014 (UTC)
Yeah... that was my main reason for not wanting to follow up on this. At best, I can point out the associations between the three as I did in the text of amphetamine, but I don't have any sources to adequately cite that causal chain of events. Besides that, there could even be another intracellular receptor that amph binds to which promotes CAMKII, which was my other reservation. In any event, I moved a lot of the CAMK articles around because Ca2+/calmodulin-dependent protein kinase was originally going to the article that I moved to Ca2+/calmodulin-dependent protein kinase II. I turned The former into a redirect to CAMK, though I'm not sure if "Ca2+/calmodulin-dependent protein kinase" or "CAMK" should be the set index for these kinases. There doesn't appear to be any general article written that includes an overview of all subtypes. CAMKI, the CAMKII family, and CAMKIV at the moment (I believe that's all the CAMKs, based upon BRENDA at least). Seppi333 (Insert  | Maintained) 02:34, 9 December 2014 (UTC)

Variability in PSA Measurement[edit]

I have edited it just because it is a very common problem occuring in practice. The review artcile may not be upto date but it is addressed considering routine problem of clinicains and lab professionals.

Copyright checks when performing AfC reviews[edit]

Hello Boghog. This message is part of a mass mailing to people who appear active in reviewing articles for creation submissions. First of all, thank you for taking part in this important work! I'm sorry this message is a form letter – it really was the only way I could think of to covey the issue economically. Of course, this also means that I have not looked to see whether the matter is applicable to you in particular.

The issue is in rather large numbers of copyright violations ("copyvios") making their way through AfC reviews without being detected (even when easy to check, and even when hallmarks of copyvios in the text that should have invited a check, were glaring). A second issue is the correct method of dealing with them when discovered.

If you don't do so already, I'd like to ask for your to help with this problem by taking on the practice of performing a copyvio check as the first step in any AfC review. The most basic method is to simply copy a unique but small portion of text from the draft body and run it through a search engine in quotation marks. Trying this from two different paragraphs is recommended. (If you have any question about whether the text was copied from the draft, rather than the other way around (a "backwards copyvio"), the Wayback Machine is very useful for sussing that out.)

If you do find a copyright violation, please do not decline the draft on that basis. Copyright violations need to be dealt with immediately as they may harm those whose content is being used and expose Wikipedia to potential legal liability. If the draft is substantially a copyvio, and there's no non-infringing version to revert to, please mark the page for speedy deletion right away using {{db-g12|url=URL of source}}. If there is an assertion of permission, please replace the draft article's content with {{subst:copyvio|url=URL of source}}.

Some of the more obvious indicia of a copyvio are use of the first person ("we/our/us..."), phrases like "this site", or apparent artifacts of content written for somewhere else ("top", "go to top", "next page", "click here", use of smartquotes, etc.); inappropriate tone of voice, such as an overly informal tone or a very slanted marketing voice with weasel words; including intellectual property symbols (™,®); and blocks of text being added all at once in a finished form with no misspellings or other errors.

I hope this message finds you well and thanks again you for your efforts in this area. Best regards--Fuhghettaboutit (talk) 02:20, 18 November 2014 (UTC).

       Sent via--MediaWiki message delivery (talk) 02:20, 18 November 2014 (UTC)

Disambiguation link notification for November 20[edit]

Hi. Thank you for your recent edits. Wikipedia appreciates your help. We noticed though that when you edited HRG (gene), you added a link pointing to the disambiguation page Rosette. Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

It's OK to remove this message. Also, to stop receiving these messages, follow these opt-out instructions. Thanks, DPL bot (talk) 14:21, 20 November 2014 (UTC)

WP:SCIRS[edit]

Boghog -- thanks for your feedback on my Quercetin edits. Respectfully, however, biochemistry is not a natural science but rather is a major field of health science at every medical school. On the WP:SCIRS page is stated "The scope of this page is limited to the natural sciences, including astronomy, biology, chemistry, geoscience, physics, and interdiscliplinary fields. For articles about medicine, see Wikipedia:Reliable sources (medicine-related articles)."

Is it a matter of interpretation or definition? The edits I removed were made on the topic of mechanisms of action of quercetin in vitro. By my experience, I'd say this is biochemistry, so WP:MEDRS applies. All Best. --Zefr (talk) 23:41, 4 December 2014 (UTC)

Respectfully, biochemistry is a natural science, not a medical science. While biochemistry is taught in medical school, biochemistry departments are normally part of colleges of liberal arts and not in medical schools. I double majored in biochemistry as an undergraduate and never attended medical school. More importantly, a biochemical mechanism of action falls within the scope of WP:MCB, not WP:MED. Boghog (talk) 23:49, 4 December 2014 (UTC)
"The scope of this page is limited to ... biology, chemistry". biology ∩ chemistry = biochemistry. Boghog (talk) 23:55, 4 December 2014 (UTC)

Disambiguation link notification for December 7[edit]

Hi. Thank you for your recent edits. Wikipedia appreciates your help. We noticed though that when you edited IGFBP3, you added a link pointing to the disambiguation page Esophageal. Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

It's OK to remove this message. Also, to stop receiving these messages, follow these opt-out instructions. Thanks, DPL bot (talk) 08:57, 7 December 2014 (UTC)

Wikipedia study- Thank you[edit]

Hello Boghog, I hope you remember speaking to me in the summer of 2012 about your motivations for contributing to the health-related pages on Wikipedia. The great news is that the study got published this Wednesday in JMIR (Journal of Medical Internet Research). You can read it here: http://www.jmir.org/2014/12/e260 This would not have been possible without your contributions so once again, I would like to thank you for taking the time and sharing your experiences with me. I also wrote an entry about my own experience with the study, about additional observations and how I plan to further extend my research - published in the WMF blog today: https://blog.wikimedia.org.uk/2014/12/who-writes-wikipedias-health-and-medical-pages-and-why/If you have any comments or questions please get in touch.Perhaps see you at the next Wikimania conference in Mexico! Best Wishes Hydra Rain (talk) 21:03, 7 December 2014 (UTC)

Merge proposal[edit]

You have proposed that Environmental fate of TNT be merged to TNT#Bio-degradation, but you have not opened a discussion regarding said merger. I have an opinion on the matter, but in the interest of maintaining a proper chronolgy of the discussion, I'd like you to open a discussion first. WikiDan61ChatMe!ReadMe!! 21:48, 11 December 2014 (UTC)

Yes check.svg Done OK, per your request, I have opened a merge discussion here. Sorry for not doing this sooner. Boghog (talk) 05:06, 12 December 2014 (UTC)