User talk:Fuse809

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Changes without an edit summary[edit]

In addition to the animated GIF I reverted, you made a series of changes to Aripiprazole without filling in the edit summary. Some of those changes may be self-explanatory, but even then, other editors can't see the changes themselves on the page history, so it's a good idea to put in a summary even then. The Crab Who Played With The Sea (talk) 09:10, 22 July 2013 (UTC)

A barnstar for you![edit]

Original Barnstar Hires.png The Original Barnstar
For your contributions to Pharmocology items, by adding structural data Sfan00 IMG (talk) 20:32, 9 August 2013 (UTC)

August 2013[edit]

Stop icon This is your last warning. The next time you disrupt Wikipedia, you may be blocked from editing without further notice. Many users have complained about your continued insertions of unusually-drawn 2D diagrams and animated 3D structures, but you have not bothered to respond. Wikipedia is a collaborative effort, where WP:CONSENSUS rules. If you decide not to participate in discussions about your edits and continue making edits that others find objectionable, you will not be permitted to edit at all. DMacks (talk) 21:21, 29 August 2013 (UTC)

OK I am trying to amend my ways, I thought that people were only upset about me uploading these images on specific pages. If I do something that people consider annoying please give me a chance to explain before you block me from editing because it is clearly unintended. Fuse809 (talk) 07:49, 9 September 2013 (UTC)

I must say, thanks DMacks, for giving me warning, plus thank you for having the manners of giving me some helpful feedback. Instead of just complaining and giving me no reasons! Fuse809 (talk) 10:05, 18 May 2014 (UTC)


Per WP:MEDRS we generally only use secondary sources like review articles and textbooks rather than primary sources. Thks Doc James (talk · contribs · email) (if I write on your page reply on mine) 14:39, 9 September 2013 (UTC)

You have had material you added removed by others for this reason aswell. I used primary sources when I first began and was corrected and adapted to this communities norm [1] Doc James (talk · contribs · email) (if I write on your page reply on mine) 00:40, 11 September 2013 (UTC)


Per the manual of style we only capatalize the first word in the lead.

Also we try to write in prose rather than lists. Not sure how to do this with side effects? Doc James (talk · contribs · email) (if I write on your page reply on mine) 01:57, 19 September 2013 (UTC)

Would also be good to write in simple language. So instead of xerostomia we can have dry mouth. Doc James (talk · contribs · email) (if I write on your page reply on mine) 09:58, 19 September 2013 (UTC)

Refs over one line[edit]

A minor point. If you put refs over one line it is easy to review changes that are made. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 21:42, 6 October 2013 (UTC)

It is easier to notices changes to the text when the ref is NOT spread out over a number of lines. See these edits as an example [2] as opposed to these [3] Doc James (talk · contribs · email) (if I write on your page reply on mine) 22:05, 6 October 2013 (UTC)


In the section headings typically only the first word is capitalized as per our WP:MOS. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 06:38, 11 October 2013 (UTC)

This is not a very good ref "Truven Health Analytics, Inc. DrugPoint® System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013." There is no link to the page / article in question. It appears closed. No indication that it is peer reviewed. We view sources like UpToDate the same. They can change and there is no record on how it was before. Doc James (talk · contribs · email) (if I write on your page reply on mine) 06:48, 11 October 2013 (UTC)
For medical content we typically use secondary sources per WP:MEDRS. Not sure why the adding of more primary sources in this edit? [4] Doc James (talk · contribs · email) (if I write on your page reply on mine) 06:58, 11 October 2013 (UTC)

DrugPoint is an accurate medical source, my university and the local hospital in my city uses it for much of its drug information. It may not be accessible to all but neither are many medical books so I don't see how this is a problem. UpToDate is peer-reviewed. Fuse809 (talk) 10:59, 11 October 2013 (UTC)

They are not static published sources. Neither of them are preferred sources. Feel free to ask others opinions at WT:MED. Better to use review articles. Doc James (talk · contribs · email) (if I write on your page reply on mine) 00:44, 12 October 2013 (UTC)


Please upload your chemical structures, etc. to Commons — as you have done in several cases before. --Leyo 08:30, 22 November 2013 (UTC)

Why don't you do so? It just causes work for other users. --Leyo 20:36, 4 December 2013 (UTC)

Usually because it makes more work for me when I'm at the upload form. Fuse809 (talk) 23:38, 4 December 2013 (UTC)

Have you ever used the prefilled form found at commons:Commons:Upload/Chemistry? It may even save time for you (and surely for others). --Leyo 09:34, 5 December 2013 (UTC)

Significant changes in meaning and values to Tricyclic antidepressant[edit]

Hi. In this series of edits you made significant changes to the above article citing only on source:

Can you please tell me what that source is and why it is reliable? Also, can you point me to where you found at least some of the categories and binding profile values that you updated? --Anthonyhcole (talk · contribs · email) 08:25, 4 December 2013 (UTC)

It is a database created by the National Institute of Mental Health and it contains a heap of Ki values and the reason why it is so reliable is because it has a large number of Ki values for each drug and the average of these values is what I used in these tables so instead of using say one journal article per piece of data (i.e. Ki value) I was using a composite of the data in a whole variety of journal articles. The categories you're mentioning is something I'm going to have to ask you to clarify as for the binding profile values I think I just answered that -- the PDSP database. I was following the algorithm for determining Ki values as was used for the Ki values in the antipsychotic chapter of Goodman and Gilman and hence I know I am using a scientifically accepted method for estimating Ki values. Fuse809 (talk) 08:44, 4 December 2013 (UTC)

This is out of my depth, so I've asked at WikiProject Molecular and Cellular Biology for someone to review your work. --Anthonyhcole (talk · contribs · email) 11:36, 4 December 2013 (UTC)
I think it is only valid to average Ki values is they are replicate measurements in the same assay from the same laboratory. In this case, it would also be appropriate to report the standard error of the mean (SEM). If these Ki values were obtained from different labs where the assay conditions may vary, then I think it would be more appropriate to report the range of values (min, max, median). Boghog (talk) 12:05, 4 December 2013 (UTC)

Doing that just crowds the tables, making them more difficult to read and can really confuse the average person. At least if we have one value and we tell them that the smaller the value the stronger the binding then they may be able to follow but if we give them ranges and SEMs we might as well through them into the deep end. I was following the method used by the authors of Goodman and Gilman and I think if it's good enough for them it's good enough for us. Fuse809 (talk) 12:26, 4 December 2013 (UTC)

OK, but at a minimum, it would be appropriate to include a footnote for each averaged table entry specifying that this value represents an average of two or more independent measurements. If a particular value is not an average, then this value should not be footnoted. Boghog (talk) 13:26, 4 December 2013 (UTC)


Why are some of the adverse effects bolded here [5]? Doc James (talk · contribs · email) (if I write on your page reply on mine) 06:08, 7 December 2013 (UTC)

Read my note and you'll know why. Fuse809 (talk) 08:32, 7 December 2013 (UTC)

Emedicine / medscape[edit]

These are passable sources sometimes but not really the best sources. Review articles or major textbooks are typically better. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 07:53, 17 April 2014 (UTC)

Also your MSR ref does not work. Doc James (talk · contribs · email) (if I write on your page reply on mine) 07:55, 17 April 2014 (UTC)

How doesn't it work? Secondly, I usually only use this ref when there's no better ref I can find. I know, I would much rather have something written than nothing. Fuse809 (talk) 08:09, 17 April 2014 (UTC)

Structure of heroin[edit]

Hi, I see that in this edit, you have replaced the molecular structure of heroin with an image you uploaded[6]. I don't know much about this but as discussed in this Help Desk question, it seems that your structure is missing the methyl part of the acetyl ester group, and instead have an -OH. Could you please check it. Thanks.···Vanischenu (mc/talk) 16:16, 17 April 2014 (UTC)

Oh so, so sorry and thank you for bringing this to my attention! I have fixed it! Fuse809 (talk) 16:40, 17 April 2014 (UTC)
Thank you! Regards···Vanischenu (mc/talk) 18:56, 17 April 2014 (UTC)


Just saw the one line in the lead being removed. Missed the rest of your changes. Sorry for the revert and apologies. Doc James (talk · contribs · email) (if I write on your page reply on mine) 17:00, 21 April 2014 (UTC)

Apology accepted; thank you for taking the time and guts to apologise, I know I probably wouldn't have bothered. Fuse809 (talk) 17:04, 21 April 2014 (UTC)

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Help me![edit]

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Hi, I'd like to know if there's anyway of getting the "Download as PDF" option for pages to actually list one's references. Additionally I'd like to know if there's any way, that any of you are aware of, of automatically creating references in the style of Wikipedia (down to the URLs given for PubMed (after PMID), PubMed Commons (after PMC) and dois (after doi:). I ask (which I'm mostly telling you so as to clarify anything confusing in how I asked my question) as I rather like Wikipedia's built-in referencing style, as it's so exhaustive, and would like to use it for my personal work. Thanks for your time, your help will be greatly appreciated!

Brenton (talk|email) (I automatically watch all pages I edit) 16:22, 31 May 2014 (UTC)

You can set up your personal wiki with the same functionality as Wikipedia; see here for the download link. Importing the {{cite doi}} and {{cite pmid}} templates isn't trivial, though. Other than that, I'm not sure what you're looking for; the only thing I could point you towards is this tool which helps create the wiki code for citations - but I don't think that's what you're looking for.
The "Download as PDF" option worked well enough for me; the PDF of the article I tested it on did include the references given in the article. Huon (talk) 19:38, 31 May 2014 (UTC)

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Hi Brenton[edit]

Hello, although I am a Chemist I really don't know how to put together a small molecule and a protein together into a 3D model in order to view interactions. Do you know how to do this? It is very important.

Best regards,

Ivan — Preceding unsigned comment added by (talk) 15:09, 10 June 2014 (UTC)

Jmol ( is the one I usually use; but it only works if and only if, there is a 3D model found in one of the two PDB file databases (, for the macromolecule-ligand complex you're interested in. Once you've downloaded the zip file I gave you the link to, then unzip it into a new direcotry and then you can open up Jmol (which you launch as an executable java file which is found in said extracted directory) then go: File->Get PDB, and type in the PDB ID of the PDB file you've found in one of these databases. Theoretically there's another route that could work, even if there is no PDB file in these libraries, but I've never done it myself as it is beyond me and frankly it would probably take anybody at least weeks to learn how to do what you're asking for themselves, but there's a free and open-source software called AutoDock ( that could theoretically do what you're asking. Brenton (talk|email) (I automatically watch all pages I edit) 18:42, 10 June 2014 (UTC)