User talk:IiKkEe

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Welcome![edit]

Hello, IiKkEe, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are a few links to pages you might find helpful:

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April 2014[edit]

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  • of blood coagulation, and in the generation of bradykinin via the[kinin-kallikrein system]]. It is inactive unless it comes in contact with binding proteins beneath the endothelial cells

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  • merge|Kininogen 1|date=November 2011}}
  • deficient in HMWK is mixed with the patient's sample and a[[ partial thromboplastin time]] PTT)]] is determined. Results are expressed in % of normal - a value under 60% indicates a deficiency.

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Your recent edits[edit]

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IiKkEe, you are invited to the Teahouse[edit]

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Hi IiKkEe! Thanks for contributing to Wikipedia.
Be our guest at the Teahouse! The Teahouse is a friendly space where new editors can ask questions about contributing to Wikipedia and get help from peers and experienced editors. I hope to see you there! Technical 13 (I'm a Teahouse host)

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Hello, IiKkEe. I read a discussion where you mentioned having difficulty getting a good answer when you asked a question. I suggest that you keep the Teahouse in mind. Although a response may occasionally be jargony and/or not truly explain an issue, this is the place where I get or read the best, most respectful answers to questions. It's meant for newbies and for persons with gaps in their Wiki-knowledge.
If you haven't yet done so, I'd like to point out that adding the appropriate number of full colons at the very beginning of your reply (and each paragraph you create in your reply) will indent your post under the comment you are addressing. It makes it easier to read and keep track of the conversation. This message has one colon at the start of each paragraph so far.
This paragraph has two colons.
This paragraph has three colons. You get the idea.
More help, including the possibility of obtaining a WP mentor: Wikipedia:Learning the ropes ; Wikipedia:Community portal ; Wikipedia:The Wikipedia Adventure a game that really can be of use if you haven't yet encountered the topics it includes ; I haven't looked at these yet, but they were recommended on the Teahouse's Talk page: User:Yunshui/About#For beginners; Category:Wikipedia help forums; Help:Contents/Directory
There is definitely an extremely steep learning curve to becoming proficient with WP. Personally, I doubt that I will ever be anywhere near the neighborhood of proficient, but so many people are that the outlook is rosie for you, as well. Thank you, Wordreader (talk) 17:51, 21 August 2014 (UTC)

Platelets[edit]

Hi, welcome and thank you for your contributions. You might find this page helpful MOS:HEAD, with regard to formatting sections. You should not use top level headings in the articles (eg. =Title=) or repeat the title of the article in headings if possible. If you need any pointers, please feel free to contact me on my Talk Page. Best wishes. Graham. Graham Colm (talk) 07:41, 13 April 2014 (UTC)

Disambiguation link notification for April 16[edit]

Hi. Thank you for your recent edits. Wikipedia appreciates your help. We noticed though that when you edited Platelet, you added a link pointing to the disambiguation page Receptor (check to confirm | fix with Dab solver). Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

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Platelet[edit]

Hi, please be careful. You didn't remove an indent with this edit [1], you broke a template. Graham Colm (talk) 19:23, 17 April 2014 (UTC)

A cup of coffee for you![edit]

A small cup of coffee.JPG Thanks for your contributions to the platelet article. I saw that you talked with another user about adding references - that is great. The Wikipedia policy has always been to expect every statement added to be associated with a cited source, even though that has not always happened. It is ideal to start with a source and then integrate it into the article piecewise. Thanks for improving the article. I know nothing about this subject but what you are doing seems thoughtful. Blue Rasberry (talk) 19:39, 17 April 2014 (UTC)

Thanks for the comments. My first edit was in mid March. I have had two others drop me notes about referencing. You are right that referencing has "not always happened": I went to the edit history section and looked at the last version before I started editing: I counted 151 unreferenced statements, and 36 referenced, which have accumulated over the past 10 years since the article was started. The count as of now, after my editing: 127 unreferenced, 37 referenced. So I have added 4 referenced statements, and deleted 28 unreferenced incorrect statements.

I have also changed numerous unreferenced statements because they were either incorrect or poorly worded. I did not reference the replacements, the logic being that for now a correct unreferenced statement is better than an incorrect unreferenced statement.

I am now finished with corrections, reorganizing and labeling. I'll take a look at referencing the statements of prior contributors as time permits.

Regards.

IiKkEe (talk) 00:28, 20 April 2014 (UTC)

platelet[edit]

please bring sources for the content you are adding - generally, and to the platelets article now. thanks! Jytdog (talk) 16:15, 19 April 2014 (UTC)

Thanks for suggestion. I have had two others drop me notes about referencing. Referencing seems to be the exception on Wikipedia, and widely tolerated: I went to the edit history section and looked at the last version of Platelet prior to my editing: I counted 151 unreferenced statements, and 36 referenced, which have accumulated over the past 10 years since the article was started. The count as of now, after my editing: 127 unreferenced, 37 referenced. So I have added 4 referenced statements, and deleted 28 unreferenced incorrect statements.

I've also changed numerous unreferenced statements because they were either incorrect or poorly worded. I did not reference the replacements, the logic being that - for now - a correct unreferenced statement is better than an incorrect unreferenced statement. I've done this on several other sites too.

Is there anyone assigned by Wikipedia to monitor for unreferenced statements, and to admonish the author or delete the statements if not referenced promptly?

I am now finished with corrections, reorganizing and labeling. I'll take a look at referencing the unreferenced statements of prior contributors as time permits.

Regards. IiKkEe (talk) 00:54, 20 April 2014 (UTC)

Hi there, thanks for your work on platelet and coagulation. I admire your energy. Don't worry about others suggesting doing stuff in a certain way. It takes a while to learn the ropes; stuff gets easier over time.
Unreferenced content is a major frustration, and you will see many articles with boxes at the top saying that the content requires references. Sadly the adding of references to existing content is a tough job, and there is no watertight formal process for addressing this. Well, unless you count the individual enthusiasm of editors who take an article and keep on hammering at it until it's fantastic and then submit it for review through the good article or featured article process.
If I can suggest one thing, it's taking the advice of experienced folk like GrahamColm (talk · contribs). He's been here for years, knows the place like no other, and happens to be professionally involved in the area of your interest. Let me know if I can be of any assistance! JFW | T@lk 14:39, 20 April 2014 (UTC)
In response to your question on people monitoring unsourced statements, there is no formal role like this. There are other editors (people like you and me) who have a peek at newly added content, and will sometimes remove stuff that looks like it's not verifiable. If it could be, and doesn't sound outrageous, it might be tagged with a {{citation needed}} tag, and sometimes the other editor might have access to the right source and add it to the unsourced statement straight away.
You can imagine that not every contribution gets "patrolled" in such a way, and this is why unsourced stuff accumulates in some articles over time. I patrol articles that I have worked on in the past, because I am usually familiar with the subject. JFW | T@lk 15:52, 20 April 2014 (UTC)

Disambiguation link notification for April 24[edit]

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Leptin[edit]

Hi IiKkEe. Thanks for all your edits to Leptin, you've done a great job improving the article. I just wanted to let you know that I have removed your warnings as it's not appropriate to include these types of comments in the article. If you have serious doubts about some of the sources you can add individual tags to each one (such as {{better source}} or {{failed verification}}) or you could remove them and add a better source. You could also place a note on the article talk page detailing all your concerns about the referencing. If you feel you must include comments in an article for any reason they should be placed in comment tags (<!-- Like this -->) so they can only be seen when someone edits the page. Sarahj2107 (talk) 19:53, 29 April 2014 (UTC)

I also noticed some of your recent edits and I was typing this message at exactly the same time as Sarahj2107 - if you think there is something fundamentally misleading with particular content, then it would be better perhaps to remove it, or to discuss its improvement on the talkpage where this could be remedied by perhaps the addition of a more up-to-date citation. There are also particular templates which can be used to highlight concerns about sourcing in articles which will be more likely to be picked up and addressed by other editors - see for example Wikipedia:Template_messages/Cleanup. I will mention this discussion at the Wikipedia talk:WikiProject Medicine, as I think someone with much more experience in this field would be better place to advise you how to achieve a sensible improvement to the article. I hope this suggestion is of help. --nonsense ferret 20:00, 29 April 2014 (UTC)

Leptin response[edit]

Well I tried to respond to Sarah under Leptin and somehow, wiki says, I am creating an edit conflict and won't let me "Save page" - so I'll start a new section to reply.

To Sarahj2107 - Thank you so much for your courtesy in notifying me what you have done. I actually did not plan to leave my warnings there: I was just documenting them for whoever wants to come behind me and try to straighten this section out. It won't be me - I know nothing about the subject of leptin resistance, but I do know how to spot the obsolete and undocumented and redundant. Everything I have done is documented in the "history of edits" section and that's good enough for me. Thanks for the "nowiki" tip: I didn't know that. Maybe there's something I know that you don't: there IS a way to mark a warning on the page itself: I just don't know how to do it. That's what I planned - and still plan - to replace my warnings with once I find out how to do it: Wiki/help/chat will tell me that. I'll just refer everyone to my "history of edit" page for the gory details.

Most of all, thanks for the compliment - everybody likes an attaboy, me included. The two things driving me crazy right now are 1) when was the AA sequence first determined and by whom? 3) what is its half life? I'll keep looking. Also, I've found some neat stuff on molecular structure vs function that I plan to add to that section, then I'll say goodbye to Ms/Mr Leptin. Unless it's to come back and admire "my" Contents section.

Regards

IiKkEe (talk) 20:58, 29 April 2014 (UTC)

Hi again, regarding your comment above, "I actually did not plan to leave my warnings there: I was just documenting them for whoever wants to come behind me and try to straighten this section out. It won't be me." You can't assume that there is an army of other volunteers in the wings ready to fix issues. There isn't one. Comments can stay on the page for years. Please try to fix errors straight away of at least start a thread on the Talk Page. We already have a disclaimer. All our contributors are just like you - working for free from home or their workplaces when there is time. Also please see WP:BRD for advice on problems that you find especially worrying. Having said all this, thanks for your hard work on Platelet, I think you are getting to know how this amazing encyclopedia has been written. Best wishes. Graham. Graham Colm (talk) 21:57, 29 April 2014 (UTC)

Talkback[edit]

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TLSuda (talk) 22:08, 29 April 2014 (UTC)

Leptin resistance first paragraph[edit]

This paragraph has four supporting references 18-28 years old. It should be rewritten by one knowledgeable in this complex and controversial area.

Refeerence 137 last sentence of page[edit]

This reference is to an online newspaper, not a peer reviewed reference

references[edit]

Imagawa, et al. Structure-Function Studies of Human Leptin. JBC. 1998, December; 52(273): 35245-35249 y Cterminal necessary for secretion, stability, solubility.

mammary epithelial cells, bone marrow, pituitary sites of leptin

Kline, et al. Leptin is a four-helix bundle: secondary structure by NMR. FEBS Letters.1997, February; 407(2): 239-242 - exhibits a short strand segment and two long random coil loops. Determined secondary structure by NMR. Long chain short helix cytokine fold.

Peelman, et al. Mapping of the leptin binding sites and design of a leptin antagonist. JBC. 2004, September; 39(279): 41038-41046 - synthesized first leptin antagonist, caused obesity, altered immune system, hypogonadism. Binding site is the N terminal 94 AA

Zhang, F., et al. Crystal Structure of the obese protein leptin-E100. Nature. 1997, May; 387(6629):206-209. First to crystallize. Leptin aggregates so cannot be crystallized . Disulfide bonding critical. structure unique

Cannot crystallize AA 27-38 As od 2008, don't fully know structure, Rigid hydrophobic core: unique. Core has a hydrophobic cap which buries the lipophilic residues on the the surface of the BD helical bundle

IiKkEe (talk) 07:35, 29 April 2014 (UTC)

note to self[edit]

Note to self 2=== Thermogenesis references[edit]

PMC3673773 - Adaptive thermogenesis 100,000 kCal stored in a 70 kg person "Cordinated regulation o energy intake and expenditure mediated by signals emanatin from adipose, gastrointestinal, and endocrine rissues, and integrated by the liver and CNS" lose weight 10% - daily energy enditre goes down 25% -lose 10% wt - gain 20% icrease in skeletal muscle chemomechanicl efficiency,18% gain in FFA use as fuel during light exsrcise PMID12609816 -UCP in BAT yilds more heat generation -BAT activation: ,beta-3 R,THR (thyroid hormone receptor) 19912477 -Leptin sensitive decline in SNS, thyrioid with weight loss COULD BE mechanism of reduced thermog. by BAT -only takes 25G of BAT to explain decline in REE -All of above applies to rodents, noy humans: little BAT im humans: YES THERE IS: BAT in 7.5% womwn, 10% men using PET scans. - Expose to cold: 23/24 have BAT on PET(19357405) - leptin prop to fat mass (8784109corti) -letin conc inv prop to hunger ratings(9822946) -give leptin, hyperphagia goes away (10486419) -Leptin goes down, intake goes up, due to more POMC, less Y(NPY) (AgRP) and (MCH)anorexogenic neuropeptitide POMC; orixigens neuropeptideY, agouti-related peptide, melanin concentrating hormone -leptin gors down,POMC goes down -low leptin meanslow HPT, high HPA -POMC proopiomelaocortin This is it: administration of leptin tolow leptinhumans causes energy expenditure up,energy intake down, SNS up, normalizes HPA, thyroid gonadalfn(11297566)(10486419) -BUT if NoT leptin def,to get a wt loss effect requires dose of L to get L conc overten times normal(10546697) -SUMMARY: lose wt, allsystems attempt to restore wt: metabolic, neuroendocrine,autonomic behavoioiural changes all oppose. FAT STORES ARE DEFENDED BY INTERLOCKINGBIOENERGETCAND NEUROBIOLOGICALPHSIOLOGIES. THe HUMAN BODY ACTIVELY OPPOSES THE CURE. - acponline.org -1999review of1320 papers , No PMID! Perfect diagrams OUTLINE GENETICS REGULATION OF SERUM LEPTIN LEVELS leptin ACTION AND CLEARANCE tHE ROLE OF LEPTIN IN HUMAN PHYSIOLOGY AND PATHOPHYSIOOGY NEONATE cHILHOOD AND PUBERTY← lEPTIN AND LEPTIN RESISTANCE IN HUMAN OBESITY lEPTIN AND THE METABOLIC AND NEUROENDOCRINE RESONSE TO FOOF DEPRIVATION l in hYPERTENSION,←DIABETES,×POLYCYSTIC OVARIAN DISEASE l IN EATING DIRORDERS L IN OTHER CLINICALSRTATES cLINICAL TRIALS FUTURE DIRECTIONS

fROM "The Role of leptin in human Mantzoros obesity and disease 199 Annala vol130 #8

IiKkEe (talk) 01:19, 30 April 2014 (UTC)

MCR - melanocortin =

Disambiguation link notification for May 3[edit]

Hi. Thank you for your recent edits. Wikipedia appreciates your help. We noticed though that when you edited Energy balance (biology), you added a link pointing to the disambiguation page ATP (check to confirm | fix with Dab solver). Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

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Imagawa, et al. Structure-Function Studies of Human Leptin. JBC. 1998, December; 52(273): 35245-35249 y

− Cterminal necessary for secretion, stability, solubility.

− − mammary epithelial cells, bone marrow, pituitary sites of leptin

− − Kline, et al. Leptin is a four-helix bundle: secondary structure by NMR. FEBS Letters.1997, February; 407(2): 239-242 - exhibits a short strand segment and two long random coil loops. Determined secondary structure by NMR. Long chain short helix cytokine fold.

− − Peelman, et al. Mapping of the leptin binding sites and design of a leptin antagonist. JBC. 2004, September; 39(279): 41038-41046 - synthesized first leptin antagonist, caused obesity, altered immune system, hypogonadism. Binding site is the N terminal 94 AA

− − Zhang, F., et al. Crystal Structure of the obese protein leptin-E100. Nature. 1997, May; 387(6629):206-209. First to crystallize. Leptin aggregates so cannot be crystallized

− . Disulfide bonding critical. structure unique

− − Cannot crystallize AA 27-38 As od 2008, don't fully know structure, Rigid hydrophobic core: unique. Core has a hydrophobic cap which buries the lipophilic residues on the the surface of the BD helical bundle

− − IiKkEe (talk) 07:35, 29 April 2014 (UTC)

Invitation[edit]

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Thank you for contributing to our articles. If you are interested in making more contributions on cell biology and biochemistry topics, you might want to join the Molecular and Cellular Biology Wikiproject (signup here). You will be most welcome. - Seppi333 (Insert  | Maintained) 04:49, 4 May 2014 (UTC)


.

Thanks for invite - I'll just stick to Platelets, Leptin, Ghrelin, and Energy homeostasis pages. Plenty enough to do there.

IiKkEe (talk) 12:44, 5 May 2014 (UTC)

Welcome!

Hello, IiKkEe! Welcome to Wikipedia! Thank you for your contributions. You may benefit from following some of the links below, which will help you get the most out of Wikipedia. If you have any questions you can ask me on my talk page, or place {{helpme}} on your talk page and ask your question there. Please remember to sign your name on talk pages by clicking or by typing four tildes "~~~~"; this will automatically produce your name and the date. If you are already excited about Wikipedia, you might want to consider being "adopted" by a more experienced editor or joining a WikiProject to collaborate with others in creating and improving articles of your interest. Click here for a directory of all the WikiProjects. Finally, please do your best to always fill in the edit summary field when making edits to pages. Happy editing! Ad Orientem (talk) 19:35, 6 May 2014 (UTC)
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May 2014[edit]

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  • combinations of the α and β subunits, around 24 unique integrins are generated.ref name="hynes1">{{cite journal |author=Hynes R |title=Integrins: bidirectional, allosteric signaling machines |
  • Integrin subunits span the [[plasma membrane]] and have short cytoplasmic domains of 40–70 [amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1088 amino

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Platelets Intro[edit]

Hi IiKkEe. . Thanks for posting to my Talk page. I have posted a reply to your suggestions on the Platelet Talk page. Thanks for contacting me and your insightful commentary. mattelfesso (talk) 08:32, 10 May 2014 (UTC)

Reference Errors on 11 May[edit]

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DRN: Ghrelin[edit]

Hi, I am a DRN volunteer. I have closed Wikipedia:Dispute resolution noticeboard#Ghrelin, as the proper place to request third party opinions is Wikipedia:Third opinion. Please see the instructions there. Also, in case you file a DRN in the future, you need to list yourself as a party, as well as those who have participated in the discussion on the particular content point in question. Good luck. --Bejnar (talk) 17:05, 14 May 2014 (UTC)

References[edit]

Medical articles on Wikipedia must be cited by the best available evidence and written in a consistent format. We typically use review articles. A list of resources to help edit such articles can be found here. The edit box has a build in citation tool to easily format references based on the PMID or ISBN, additionally, the Citation Template Generator will aid in the formatting of references; all one needs to do is cut and paste the results. The welcome page is another good place to learn about editing the encyclopedia. If you have any questions, please feel free to drop me a note. Doc James (talk · contribs · email) (if I write on your page reply on mine) 08:09, 28 August 2014 (UTC)

So do you refuse to use references? And follow WP:MEDMOS? Why? Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 08:13, 28 August 2014 (UTC)

August 2014[edit]

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