VAMP1

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Vesicle-associated membrane protein 1 (synaptobrevin 1)
Protein VAMP1 PDB 1kil.png
PDB rendering based on 1kil.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols VAMP1 ; SPAX1; SYB1; VAMP-1
External IDs OMIM185880 MGI1313276 HomoloGene40678 ChEMBL: 2038 GeneCards: VAMP1 Gene
RNA expression pattern
PBB GE VAMP1 207101 at tn.png
PBB GE VAMP1 213326 at tn.png
PBB GE VAMP1 207100 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6843 22317
Ensembl ENSG00000139190 ENSMUSG00000030337
UniProt P23763 Q62442
RefSeq (mRNA) NM_001297438 NM_001080557
RefSeq (protein) NP_001284367 NP_001074026
Location (UCSC) Chr 12:
6.57 – 6.58 Mb
Chr 6:
125.22 – 125.24 Mb
PubMed search [1] [2]

Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.[1][2]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

References[edit]

  1. ^ Archer BT 3rd, Ozcelik T, Jahn R, Francke U, Sudhof TC (Nov 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J Biol Chem 265 (28): 17267–73. PMID 1976629. 
  2. ^ a b "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)". 

Further reading[edit]