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Vesicle-associated membrane protein 4
Protein VAMP4 PDB 2nps.png
PDB rendering based on 2nps.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VAMP4 ; VAMP-4; VAMP24
External IDs OMIM606909 MGI1858730 HomoloGene37847 GeneCards: VAMP4 Gene
RNA expression pattern
PBB GE VAMP4 207350 s at tn.png
PBB GE VAMP4 213480 at tn.png
More reference expression data
Species Human Mouse
Entrez 8674 53330
Ensembl ENSG00000117533 ENSMUSG00000026696
UniProt O75379 O70480
RefSeq (mRNA) NM_001185127 NM_016796
RefSeq (protein) NP_001172056 NP_058076
Location (UCSC) Chr 1:
171.67 – 171.71 Mb
Chr 1:
162.57 – 162.6 Mb
PubMed search [1] [2]

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.[1][2]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.[2]


VAMP4 has been shown to interact with AP1M1,[3] STX6[4] and STX16.[4]


  1. ^ Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (May 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". J Biol Chem 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086. 
  2. ^ a b "Entrez Gene: VAMP4 vesicle-associated membrane protein 4". 
  3. ^ Hinners, Ina; Wendler Franz; Fei Hao; Thomas Laurel; Thomas Gary; Tooze Sharon A (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep. (England) 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. ISSN 1469-221X. PMC 1326413. PMID 14608369. 
  4. ^ a b Mallard, Frédéric; Tang Bor Luen, Galli Thierry, Tenza Danièle, Saint-Pol Agnès, Yue Xu, Antony Claude, Hong Wanjin, Goud Bruno, Johannes Ludger (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. (United States) 156 (4): 653–64. doi:10.1083/jcb.200110081. ISSN 0021-9525. PMC 2174079. PMID 11839770. 

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