VAMP4
From Wikipedia, the free encyclopedia
| Vesicle-associated membrane protein 4 | |||||||||||
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 PDB rendering based on 2nps. |
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| Identifiers | |||||||||||
| Symbols | VAMP4; VAMP-4; VAMP24 | ||||||||||
| External IDs | OMIM: 606909 MGI: 1858730 HomoloGene: 37847 GeneCards: VAMP4 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 8674 | 53330 | |||||||||
| Ensembl | ENSG00000117533 | ENSMUSG00000026696 | |||||||||
| UniProt | O75379 | Q9D095 | |||||||||
| RefSeq (mRNA) | NM_001185127.1 | NM_016796.3 | |||||||||
| RefSeq (protein) | NP_001172056.1 | NP_058076.2 | |||||||||
| Location (UCSC) | Chr 1: 171.67 – 171.71 Mb |
Chr 1: 164.5 – 164.53 Mb |
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| PubMed search | [1] | [2] | |||||||||
Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.[1][2]
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.[2]
[edit] Interactions
VAMP4 has been shown to interact with AP1M1,[3] STX6[4] and STX16.[4]
[edit] References
- ^ Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (May 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". J Biol Chem 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
- ^ a b "Entrez Gene: VAMP4 vesicle-associated membrane protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8674.
- ^ Hinners, Ina; Wendler Franz, Fei Hao, Thomas Laurel, Thomas Gary, Tooze Sharon A (Dec. 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep. (England) 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. ISSN 1469-221X. PMC 1326413. PMID 14608369. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1326413.
- ^ a b Mallard, Frédéric; Tang Bor Luen, Galli Thierry, Tenza Danièle, Saint-Pol Agnès, Yue Xu, Antony Claude, Hong Wanjin, Goud Bruno, Johannes Ludger (Feb. 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. (United States) 156 (4): 653–64. doi:10.1083/jcb.200110081. ISSN 0021-9525. PMC 2174079. PMID 11839770. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174079.
[edit] Further reading
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
- Steegmaier M, Klumperman J, Foletti DL, et al. (1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking". Mol. Biol. Cell 10 (6): 1957–72. PMC 25394. PMID 10359608. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25394.
- Scales SJ, Chen YA, Yoo BY, et al. (2000). "SNAREs contribute to the specificity of membrane fusion". Neuron 26 (2): 457–64. doi:10.1016/S0896-6273(00)81177-0. PMID 10839363.
- Peden AA, Park GY, Scheller RH (2002). "The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding". J. Biol. Chem. 276 (52): 49183–7. doi:10.1074/jbc.M106646200. PMID 11598115.
- Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174079.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Zeng Q, Tran TT, Tan HX, Hong W (2003). "The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network". J. Biol. Chem. 278 (25): 23046–54. doi:10.1074/jbc.M303214200. PMID 12682051.
- Hinners I, Wendler F, Fei H, et al. (2004). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1326413.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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