VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C
Identifiers
Symbols	VAPB; ALS8; VAMP-B; VAP-B
External IDs	OMIM: 605704 MGI: 1928744 HomoloGene: 36163 GeneCards: VAPB Gene
Gene Ontology Molecular function • structural molecule activity • protein binding • enzyme binding • protein homodimerization activity • protein heterodimerization activity • beta-tubulin binding Cellular component • membrane fraction • endoplasmic reticulum • endoplasmic reticulum membrane • endoplasmic reticulum membrane • endoplasmic reticulum membrane • Golgi apparatus • membrane • integral to membrane Biological process • sphingolipid metabolic process • cell death • virus-host interaction • endoplasmic reticulum unfolded protein response • interspecies interaction between organisms • positive regulation of viral genome replication Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9217	56491
Ensembl	ENSG00000124164	ENSMUSG00000054455
UniProt	O95292	Q3TA54
RefSeq (mRNA)	NM_001195677.1	NM_019806.5
RefSeq (protein)	NP_001182606.1	NP_062780.2
Location (UCSC)	Chr 20: 56.96 – 57.03 Mb	Chr 2: 173.56 – 173.61 Mb
PubMed search	[1]	[2]

Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene.

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.. The VAPB gene is found on the 20th human chromosome.

Further reading

• Bastepe M, Pincus JE, Jüppner H (2000). "Two frequent tetra-nucleotide repeat polymorphisms between VAPB and STX16 on chromosome 20q13.". Mol. Cell. Probes 13 (6): 449–51. doi:10.1006/mcpr.1999.0271. PMID 10657150. 
• Paumet F, Le Mao J, Martin S, et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment.". J. Immunol. 164 (11): 5850–7. PMID 10820264. 
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Polgár J, Chung SH, Reed GL (2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.". Blood 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. PMID 12130530. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Nishimura AL, Mitne-Neto M, Silva HC, et al. (2004). "A novel locus for late onset amyotrophic lateral sclerosis/motor neurone disease variant at 20q13.". J. Med. Genet. 41 (4): 315–20. doi:10.1136/jmg.2003.013029. PMC 1735732. PMID 15060112. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1735732. 
• Nishimura AL, Mitne-Neto M, Silva HC, et al. (2005). "A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.". Am. J. Hum. Genet. 75 (5): 822–31. doi:10.1086/425287. PMC 1182111. PMID 15372378. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1182111. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Amarilio R, Ramachandran S, Sabanay H, Lev S (2005). "Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction.". J. Biol. Chem. 280 (7): 5934–44. doi:10.1074/jbc.M409566200. PMID 15545272. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Hamamoto I, Nishimura Y, Okamoto T, et al. (2005). "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.". J. Virol. 79 (21): 13473–82. doi:10.1128/JVI.79.21.13473-13482.2005. PMC 1262604. PMID 16227268. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1262604. 
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365. 
• Perry RJ, Ridgway ND (2006). "Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.". Mol. Biol. Cell 17 (6): 2604–16. doi:10.1091/mbc.E06-01-0060. PMC 1474796. PMID 16571669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1474796. 
• Conforti FL, Sprovieri T, Mazzei R, et al. (2006). "Sporadic ALS is not associated with VAPB gene mutations in Southern Italy.". Journal of negative results in biomedicine 5: 7. doi:10.1186/1477-5751-5-7. PMC 1481594. PMID 16729899. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1481594. 
• Kanekura K, Nishimoto I, Aiso S, Matsuoka M (2006). "Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).". J. Biol. Chem. 281 (40): 30223–33. doi:10.1074/jbc.M605049200. PMID 16891305.