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Vav 2 guanine nucleotide exchange factor
Protein VAV2 PDB 2dlz.png
PDB rendering based on 2dlz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VAV2 ; VAV-2
External IDs OMIM600428 MGI102718 HomoloGene2530 GeneCards: VAV2 Gene
RNA expression pattern
PBB GE VAV2 205536 at tn.png
PBB GE VAV2 205537 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7410 22325
Ensembl ENSG00000160293 ENSMUSG00000009621
UniProt P52735 Q60992
RefSeq (mRNA) NM_001134398 NM_009500
RefSeq (protein) NP_001127870 NP_033526
Location (UCSC) Chr 9:
136.63 – 136.86 Mb
Chr 2:
27.26 – 27.43 Mb
PubMed search [1] [2]

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.[1][2]

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.[2]


VAV2 has been shown to interact with CD19[3] and Grb2.[4][5]


  1. ^ Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982. 
  2. ^ a b "Entrez Gene: VAV2 vav 2 oncogene". 
  3. ^ Doody, G M; Billadeau D D; Clayton E; Hutchings A; Berland R; McAdam S; Leibson P J; Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. (ENGLAND) 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163. 
  4. ^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. (United States) 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. 
  5. ^ Bourguignon, L Y; Zhu H; Zhou B; Diedrich F; Singleton P A; Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. (United States) 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575. 

Further reading[edit]