VCAM-1

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Vascular cell adhesion molecule 1
Protein VCAM1 PDB 1ij9.png
PDB rendering based on 1ij9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols VCAM1 ; CD106; INCAM-100
External IDs OMIM192225 MGI98926 HomoloGene838 ChEMBL: 3735 GeneCards: VCAM1 Gene
RNA expression pattern
PBB GE VCAM1 203868 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7412 22329
Ensembl ENSG00000162692 ENSMUSG00000027962
UniProt P19320 P29533
RefSeq (mRNA) NM_001078 NM_011693
RefSeq (protein) NP_001069 NP_035823
Location (UCSC) Chr 1:
101.19 – 101.2 Mb
Chr 3:
116.11 – 116.13 Mb
PubMed search [1] [2]

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.[1] VCAM-1 functions as a cell adhesion molecule.

Structure[edit]

The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans.[2] The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.

Function[edit]

The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Upregulation of VCAM-1 in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem NF-κB (nuclear factor-kappa B) sites. The sustained expression of VCAM-1 lasts over 24 hours.

Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR[3] and Moesin.[3]

Pharmacology[edit]

Certain melanoma cells can use VCAM-1 to adhere to the endothelium, and VCAM-1 may participate in monocyte recruitment to atherosclerotic sites. As a result, VCAM-1 is a potential drug target.

References[edit]

  1. ^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T (1991). "The human VCAM1 gene is assigned to chromosome 1p31-p32". Cytogenet. Cell Genet. 58: 1852. doi:10.1159/000133735. 
  2. ^ "Entrez Gene: VCAM1 vascular cell adhesion molecule 1". 
  3. ^ a b Barreiro, Olga; Yanez-Mo Maria, Serrador Juan M, Montoya Maria C, Vicente-Manzanares Miguel, Tejedor Reyes, Furthmayr Heinz, Sanchez-Madrid Francisco (Jun 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes". J. Cell Biol. (United States) 157 (7): 1233–45. doi:10.1083/jcb.200112126. ISSN 0021-9525. PMC 2173557. PMID 12082081. 

Further reading[edit]

External links[edit]