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Voltage-dependent anion channel 1
Protein VDAC1 PDB 2JK4.png
Rendering based on PDB 2JK4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VDAC1 ; PORIN; VDAC-1
External IDs OMIM604492 MGI106919 HomoloGene107244 GeneCards: VDAC1 Gene
RNA expression pattern
PBB GE VDAC1 212038 s at tn.png
PBB GE VDAC1 217140 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7416 22333
Ensembl ENSG00000073905 ENSMUSG00000020402
UniProt P21796 Q60932
RefSeq (mRNA) NM_003374 NM_011694
RefSeq (protein) NP_003365 NP_035824
Location (UCSC) Chr 5:
133.31 – 133.34 Mb
Chr 11:
52.36 – 52.39 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 1 is a protein that in humans is encoded by the VDAC1 gene.[1][2]

See also[edit]


VDAC1 has been shown to interact with Gelsolin,[3] BCL2-like 1,[4][5][6][7] PRKCE,[8] Bcl-2-associated X protein[4][5] and DYNLT3.[9]


  1. ^ Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (July 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385. 
  2. ^ "Entrez Gene: VDAC1 voltage-dependent anion channel 1". 
  3. ^ Kusano, H; Shimizu S, Koya R C, Fujita H, Kamada S, Kuzumaki N, Tsujimoto Y (October 2000). "Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC". Oncogene (ENGLAND) 19 (42): 4807–14. doi:10.1038/sj.onc.1203868. ISSN 0950-9232. PMID 11039896. 
  4. ^ a b Weng, Changjiang; Li Yuan, Xu Dan, Shi Yong, Tang Hong (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells". J. Biol. Chem. (United States) 280 (11): 10491–500. doi:10.1074/jbc.M412819200. ISSN 0021-9258. PMID 15637055. 
  5. ^ a b Shi, Yong; Chen Jianjun, Weng Changjiang, Chen Rui, Zheng Yanhua, Chen Quan, Tang Hong (June 2003). "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochem. Biophys. Res. Commun. (United States) 305 (4): 989–96. doi:10.1016/S0006-291X(03)00871-4. ISSN 0006-291X. PMID 12767928. 
  6. ^ Shimizu, S; Konishi A, Kodama T, Tsujimoto Y (March 2000). "BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3100–5. doi:10.1073/pnas.97.7.3100. ISSN 0027-8424. PMC 16199. PMID 10737788. 
  7. ^ Shimizu, S; Narita M, Tsujimoto Y (June 1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC". Nature (ENGLAND) 399 (6735): 483–7. doi:10.1038/20959. ISSN 0028-0836. PMID 10365962. 
  8. ^ Baines, Christopher P; Song Chang-Xu, Zheng Yu-Ting, Wang Guang-Wu, Zhang Jun, Wang Ou-Li, Guo Yiru, Bolli Roberto, Cardwell Ernest M, Ping Peipei (May 2003). "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria". Circ. Res. (United States) 92 (8): 873–80. doi:10.1161/01.RES.0000069215.36389.8D. PMID 12663490. 
  9. ^ Schwarzer, Christian; Barnikol-Watanabe Shitsu, Thinnes Friedrich P, Hilschmann Norbert (September 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. (England) 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. 

Further reading[edit]

External links[edit]