VDAC1

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Voltage-dependent anion channel 1
Protein VDAC1 PDB 2JK4.png
Rendering based on PDB 2JK4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols VDAC1 ; PORIN; VDAC-1
External IDs OMIM604492 MGI106919 HomoloGene107244 GeneCards: VDAC1 Gene
RNA expression pattern
PBB GE VDAC1 212038 s at tn.png
PBB GE VDAC1 217140 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7416 22333
Ensembl ENSG00000073905 ENSMUSG00000020402
UniProt P21796 Q60932
RefSeq (mRNA) NM_003374 NM_011694
RefSeq (protein) NP_003365 NP_035824
Location (UCSC) Chr 5:
133.31 – 133.34 Mb
Chr 11:
52.36 – 52.39 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 1 is a protein that in humans is encoded by the VDAC1 gene.[1][2]

Interactions[edit]

VDAC1 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (July 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385. 
  2. ^ "Entrez Gene: VDAC1 voltage-dependent anion channel 1". 
  3. ^ a b Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells". J. Biol. Chem. 280 (11): 10491–500. doi:10.1074/jbc.M412819200. PMID 15637055. 
  4. ^ a b Shi Y, Chen J, Weng C, Chen R, Zheng Y, Chen Q et al. (June 2003). "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochem. Biophys. Res. Commun. 305 (4): 989–96. doi:10.1016/s0006-291x(03)00871-4. PMID 12767928. 
  5. ^ Shimizu S, Konishi A, Kodama T, Tsujimoto Y (March 2000). "BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3100–5. doi:10.1073/pnas.97.7.3100. PMC 16199. PMID 10737788. 
  6. ^ Shimizu S, Narita M, Tsujimoto Y (June 1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC". Nature 399 (6735): 483–7. doi:10.1038/20959. PMID 10365962. 
  7. ^ Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (September 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/s1357-2725(02)00026-2. PMID 12009301. 
  8. ^ Kusano H, Shimizu S, Koya RC, Fujita H, Kamada S, Kuzumaki N et al. (October 2000). "Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC". Oncogene 19 (42): 4807–14. doi:10.1038/sj.onc.1203868. PMID 11039896. 
  9. ^ Baines CP, Song CX, Zheng YT, Wang GW, Zhang J, Wang OL et al. (May 2003). "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria". Circ. Res. 92 (8): 873–80. doi:10.1161/01.RES.0000069215.36389.8D. PMC 3691672. PMID 12663490. 


Further reading[edit]

External links[edit]