From Wikipedia, the free encyclopedia
Jump to: navigation, search
Voltage-dependent anion channel 1
Protein VDAC1 PDB 2JK4.png
Rendering based on PDB 2JK4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VDAC1 ; PORIN; VDAC-1
External IDs OMIM604492 MGI106919 HomoloGene107244 GeneCards: VDAC1 Gene
RNA expression pattern
PBB GE VDAC1 212038 s at tn.png
PBB GE VDAC1 217140 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7416 22333
Ensembl ENSG00000073905 ENSMUSG00000020402
UniProt P21796 Q60932
RefSeq (mRNA) NM_003374 NM_011694
RefSeq (protein) NP_003365 NP_035824
Location (UCSC) Chr 5:
133.31 – 133.34 Mb
Chr 11:
52.36 – 52.39 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 1 is a protein that in humans is encoded by the VDAC1 gene.[1][2]

See also[edit]


VDAC1 has been shown to interact with Gelsolin,[3] BCL2-like 1,[4][5][6][7] PRKCE,[8] Bcl-2-associated X protein[4][5] and DYNLT3.[9]


  1. ^ Blachly-Dyson E, Baldini A, Litt M, McCabe ER, Forte M (July 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385. 
  2. ^ "Entrez Gene: VDAC1 voltage-dependent anion channel 1". 
  3. ^ Kusano, H; Shimizu S; Koya R C; Fujita H; Kamada S; Kuzumaki N; Tsujimoto Y (October 2000). "Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC". Oncogene (ENGLAND) 19 (42): 4807–14. doi:10.1038/sj.onc.1203868. ISSN 0950-9232. PMID 11039896. 
  4. ^ a b Weng, Changjiang; Li Yuan; Xu Dan; Shi Yong; Tang Hong (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells". J. Biol. Chem. (United States) 280 (11): 10491–500. doi:10.1074/jbc.M412819200. ISSN 0021-9258. PMID 15637055. 
  5. ^ a b Shi, Yong; Chen Jianjun; Weng Changjiang; Chen Rui; Zheng Yanhua; Chen Quan; Tang Hong (June 2003). "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochem. Biophys. Res. Commun. (United States) 305 (4): 989–96. doi:10.1016/S0006-291X(03)00871-4. ISSN 0006-291X. PMID 12767928. 
  6. ^ Shimizu, S; Konishi A; Kodama T; Tsujimoto Y (March 2000). "BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3100–5. doi:10.1073/pnas.97.7.3100. ISSN 0027-8424. PMC 16199. PMID 10737788. 
  7. ^ Shimizu, S; Narita M; Tsujimoto Y (June 1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC". Nature (ENGLAND) 399 (6735): 483–7. doi:10.1038/20959. ISSN 0028-0836. PMID 10365962. 
  8. ^ Baines, Christopher P; Song Chang-Xu; Zheng Yu-Ting; Wang Guang-Wu; Zhang Jun; Wang Ou-Li; Guo Yiru; Bolli Roberto; Cardwell Ernest M; Ping Peipei (May 2003). "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria". Circ. Res. (United States) 92 (8): 873–80. doi:10.1161/01.RES.0000069215.36389.8D. PMID 12663490. 
  9. ^ Schwarzer, Christian; Barnikol-Watanabe Shitsu, Thinnes Friedrich P, Hilschmann Norbert (September 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. (England) 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. 

Further reading[edit]

External links[edit]