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Voltage-dependent anion channel 1
Protein VDAC1 PDB 2JK4.png
Rendering based on PDB 2JK4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VDAC1 ; PORIN; VDAC-1
External IDs OMIM604492 MGI106919 HomoloGene107244 GeneCards: VDAC1 Gene
RNA expression pattern
PBB GE VDAC1 212038 s at tn.png
PBB GE VDAC1 217140 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7416 22333
Ensembl ENSG00000073905 ENSMUSG00000020402
UniProt P21796 Q60932
RefSeq (mRNA) NM_003374 NM_011694
RefSeq (protein) NP_003365 NP_035824
Location (UCSC) Chr 5:
133.31 – 133.34 Mb
Chr 11:
52.36 – 52.39 Mb
PubMed search [1] [2]

Voltage-dependent anion-selective channel protein 1 is a protein that in humans is encoded by the VDAC1 gene.[1][2]


VDAC1 has been shown to interact with:

See also[edit]


  1. ^ Blachly-Dyson E, Baldini A, Litt M, McCabe E, Forte M (July 1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385. 
  2. ^ "Entrez Gene: VDAC1 voltage-dependent anion channel 1". 
  3. ^ a b Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells". J. Biol. Chem. 280 (11): 10491–500. doi:10.1074/jbc.M412819200. PMID 15637055. 
  4. ^ a b Shi Y, Chen J, Weng C, Chen R, Zheng Y, Chen Q et al. (June 2003). "Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins". Biochem. Biophys. Res. Commun. 305 (4): 989–96. PMID 12767928. 
  5. ^ Shimizu S, Konishi A, Kodama T, Tsujimoto Y (March 2000). "BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3100–5. PMC 16199. PMID 10737788. 
  6. ^ Shimizu S, Narita M, Tsujimoto Y (June 1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC". Nature 399 (6735): 483–7. doi:10.1038/20959. PMID 10365962. 
  7. ^ Schwarzer C, Barnikol-Watanabe S, Thinnes F, Hilschmann N (September 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. PMID 12009301. 
  8. ^ Kusano H, Shimizu S, Koya R, Fujita H, Kamada S, Kuzumaki N et al. (October 2000). "Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC". Oncogene 19 (42): 4807–14. doi:10.1038/sj.onc.1203868. PMID 11039896. 
  9. ^ Baines C, Song C, Zheng Y, Wang G, Zhang J, Wang O et al. (May 2003). "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria". Circ. Res. 92 (8): 873–80. doi:10.1161/01.RES.0000069215.36389.8D. PMC 3691672. PMID 12663490. 

Further reading[edit]

External links[edit]