C-fos induced growth factor

C-fos induced growth factor (vascular endothelial growth factor D)
Identifiers
Symbols	FIGF; VEGF-D; VEGFD
External IDs	OMIM: 300091 MGI: 108037 HomoloGene: 3288 GeneCards: FIGF Gene
Gene Ontology Molecular function • platelet-derived growth factor receptor binding • growth factor activity • chemoattractant activity Cellular component • extracellular region • extracellular space • membrane • platelet alpha granule lumen Biological process • angiogenesis • platelet degranulation • multicellular organismal development • blood coagulation • positive regulation of cell proliferation • cell differentiation • platelet activation • vascular endothelial growth factor receptor signaling pathway • positive chemotaxis • induction of positive chemotaxis • positive regulation of cell division • positive regulation of mast cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2277	14205
Ensembl	ENSG00000165197	ENSMUSG00000031380
UniProt	O43915	Q6P5N9
RefSeq (mRNA)	NM_004469	NM_010216.1
RefSeq (protein)	NP_004460	NP_034346.1
Location (UCSC)	Chr X: 15.36 – 15.4 Mb	Chr X: 160.81 – 160.84 Mb
PubMed search	[1]	[2]

C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Orlandini M, Marconcini L, Ferruzzi R, Oliviero S (1996). "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11675–80. doi:10.1073/pnas.93.21.11675. PMC 38117. PMID 8876195. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38117. 
• Yamada Y, Nezu J, Shimane M, Hirata Y (1997). "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D". Genomics 42 (3): 483–8. doi:10.1006/geno.1997.4774. PMID 9205122. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Achen MG, Jeltsch M, Kukk E et al (1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548–53. doi:10.1073/pnas.95.2.548. PMC 18457. PMID 9435229. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18457. 
• Rocchigiani M, Lestingi M, Luddi A et al (1998). "Human FIGF: cloning, gene structure, and mapping to chromosome Xp22.1 between the PIGA and the GRPR genes". Genomics 47 (2): 207–16. doi:10.1006/geno.1997.5079. PMID 9479493. 
• Stacker SA, Stenvers K, Caesar C et al (1999). "Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers". J. Biol. Chem. 274 (45): 32127–36. doi:10.1074/jbc.274.45.32127. PMID 10542248. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Nakamura Y, Yasuoka H, Tsujimoto M et al (2003). "Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up". Clin. Cancer Res. 9 (2): 716–21. PMID 12576440. 
• Yokoyama Y, Charnock-Jones DS, Licence D et al (2003). "Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma". Br. J. Cancer 88 (2): 237–44. doi:10.1038/sj.bjc.6600701. PMC 2377043. PMID 12610509. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2377043. 
• Rissanen TT, Markkanen JE, Gruchala M et al (2003). "VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses". Circ. Res. 92 (10): 1098–106. doi:10.1161/01.RES.0000073584.46059.E3. PMID 12714562. 
• Funaki H, Nishimura G, Harada S et al (2003). "Expression of vascular endothelial growth factor D is associated with lymph node metastasis in human colorectal carcinoma". Oncology 64 (4): 416–22. doi:10.1159/000070301. PMID 12759540. 
• Orlandini M, Semboloni S, Oliviero S (2004). "Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability". J. Biol. Chem. 278 (45): 44650–6. doi:10.1074/jbc.M304255200. PMID 12920128. 
• McColl BK, Baldwin ME, Roufail S et al (2003). "Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D". J. Exp. Med. 198 (6): 863–8. doi:10.1084/jem.20030361. PMC 2194198. PMID 12963694. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2194198. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Vlahakis NE, Young BA, Atakilit A, Sheppard D (2005). "The lymphangiogenic growth factors VEGF-C and D are ligands for the integrin α9β1". J. Biol. Chem. 280 (6): 4544–52. doi:10.1074/jbc.M412816200. PMC 1368959. PMID 15590642. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1368959. 
• Kurahara H, Takao S, Maemura K et al (2005). "Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis". Clin. Cancer Res. 10 (24): 8413–20. doi:10.1158/1078-0432.CCR-04-0379. PMID 15623620. 
• Fink AM, Kaltenegger I, Schneider B et al (2005). "Serum level of VEGF-D in patients with primary lymphedema". Lymphology 37 (4): 185–9. PMID 15693535. 
• Kaushal V, Mukunyadzi P, Dennis RA et al (2005). "Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease". Clin. Cancer Res. 11 (2 Pt 1): 584–93. PMID 15701844. 
• Yasuoka H, Nakamura Y, Zuo H et al (2005). "VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma". Mod. Pathol. 18 (8): 1127–33. doi:10.1038/modpathol.3800402. PMID 15803188.