Mitochondrial antiviral-signaling protein

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Mitochondrial antiviral signaling protein
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM609676 MGI2444773 HomoloGene17004 GeneCards: MAVS Gene
RNA expression pattern
PBB GE VISA gnf1h08693 at tn.png
PBB GE VISA gnf1h08694 at tn.png
More reference expression data
Species Human Mouse
Entrez 57506 228607
Ensembl ENSG00000088888 ENSMUSG00000037523
UniProt Q7Z434 Q8VCF0
RefSeq (mRNA) NM_001206491 NM_001206382
RefSeq (protein) NP_001193420 NP_001193311
Location (UCSC) Chr 20:
3.83 – 3.85 Mb
Chr 2:
131.23 – 131.25 Mb
PubMed search [1] [2]

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene.[1][2][3] The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate IRF3 dimerization.[4]


Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate NFKB, or TBK1 and IKBKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound MAVS.[3][5]


  1. ^ Seth RB, Sun L, Ea CK, Chen ZJ (Sep 2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3". Cell 122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID 16125763. 
  2. ^ Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB (Sep 2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling". Mol Cell 19 (6): 727–40. doi:10.1016/j.molcel.2005.08.014. PMID 16153868. 
  3. ^ a b "Entrez Gene: VISA virus-induced signaling adapter". 
  4. ^ Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (Aug 5, 2011). "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.". Cell 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231. 
  5. ^ Sen GC, Sarkar SN (2005). "Hitching RIG to action". Nat. Immunol. 6 (11): 1074–6. doi:10.1038/ni1105-1074. PMID 16239922. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.