VNN2

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Vanin 2
Identifiers
Symbols VNN2 ; FOAP-4; GPI-80
External IDs OMIM603571 MGI1347055 HomoloGene130041 GeneCards: VNN2 Gene
EC number 3.5.1.92
RNA expression pattern
PBB GE VNN2 205922 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8875 26464
Ensembl ENSG00000112303 ENSMUSG00000020010
UniProt O95498 Q9QZ25
RefSeq (mRNA) NM_001242350 NM_011979.2
RefSeq (protein) NP_001229279 NP_036109.3
Location (UCSC) Chr 6:
133.07 – 133.08 Mb
Chr 10:
23.57 – 23.59 Mb
PubMed search [1] [2]

Vascular non-inflammatory molecule 2 is a protein that in humans is encoded by the VNN2 gene.[1][2][3]

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.[3]

References[edit]

  1. ^ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769. 
  2. ^ Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (Aug 2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. 
  3. ^ a b "Entrez Gene: VNN2 vanin 2". 

Further reading[edit]