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Vpr (HIV-1) binding protein
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VPRBP ; DCAF1
External IDs MGI2445220 HomoloGene8805 GeneCards: VPRBP Gene
EC number
Species Human Mouse
Entrez 9730 321006
Ensembl ENSG00000145041 ENSMUSG00000040325
UniProt Q9Y4B6 Q80TR8
RefSeq (mRNA) NM_001171904 NM_001015507
RefSeq (protein) NP_001165375 NP_001015507
Location (UCSC) Chr 3:
51.43 – 51.53 Mb
Chr 9:
106.82 – 106.88 Mb
PubMed search [1] [2]

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.[1][2][3]


VPRBP has been shown to interact with Merlin.[4]


  1. ^ Zhao LJ, Mukherjee S, Narayan O (Jun 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". J Biol Chem 269 (22): 15577–82. PMID 8195203. 
  2. ^ Zhang S, Feng Y, Narayan O, Zhao LJ (Mar 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene 263 (1-2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251. 
  3. ^ "Entrez Gene: VPRBP Vpr (HIV-1) binding protein". 
  4. ^ Huang, J; Chen J (Jul 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene (England) 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868. 

Further reading[edit]