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Pre-B lymphocyte 3
Symbols VPREB3 ; 8HS20; N27C7-2
External IDs OMIM605017 MGI98938 HomoloGene7598 GeneCards: VPREB3 Gene
RNA expression pattern
PBB GE VPREB3 220068 at tn.png
More reference expression data
Species Human Mouse
Entrez 29802 22364
Ensembl ENSG00000128218 ENSMUSG00000000903
UniProt Q9UKI3 n/a
RefSeq (mRNA) NM_013378 NM_009514
RefSeq (protein) NP_037510 NP_033540
Location (UCSC) Chr 22:
24.09 – 24.1 Mb
Chr 10:
75.94 – 75.95 Mb
PubMed search [1] [2]

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.[1][2][3]

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.[3]


  1. ^ Rosnet O, Mattei MG, Delattre O, Schiff C (Apr 2000). "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse". Cytogenet Cell Genet 87 (3–4): 205–8. doi:10.1159/000015468. PMID 10702669. 
  2. ^ Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C (Mar 2004). "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells". J Biol Chem 279 (11): 10228–36. doi:10.1074/jbc.M312169-A200. PMID 14670953. 
  3. ^ a b "Entrez Gene: VPREB3 pre-B lymphocyte gene 3". 

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