VPS18
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| Vacuolar protein sorting 18 homolog (S. cerevisiae) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | VPS18; KIAA1475; PEP3 | ||||||||||||
| External IDs | OMIM: 608551 MGI: 2443626 HomoloGene: 13302 GeneCards: VPS18 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 57617 | 228545 | |||||||||||
| Ensembl | ENSG00000104142 | ENSMUSG00000034216 | |||||||||||
| UniProt | Q9P253 | Q3U7D9 | |||||||||||
| RefSeq (mRNA) | NM_020857 | NM_172269.3 | |||||||||||
| RefSeq (protein) | NP_065908 | NP_758473.3 | |||||||||||
| Location (UCSC) | Chr 15: 41.19 – 41.2 Mb |
Chr 2: 119.11 – 119.12 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.[1][2][3]
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[3]
[edit] Interactions
VPS18 has been shown to interact with VPS11[4] and STX7.[4]
[edit] References
- ^ Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Kramer H (Mar 2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
- ^ Yogosawa S, Hatakeyama S, Nakayama KI, Miyoshi H, Kohsaka S, Akazawa C (Dec 2005). "Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase". J Biol Chem 280 (50): 41619–27. doi:10.1074/jbc.M508397200. PMID 16203730.
- ^ a b "Entrez Gene: VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57617.
- ^ a b Kim, B Y; Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (Aug. 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. (United States) 276 (31): 29393–402. doi:10.1074/jbc.M101778200. ISSN 0021-9258. PMID 11382755.
[edit] Further reading
- Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
- Kim BY, Krämer H, Yamamoto A, et al. (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kim BY, Ueda M, Kominami E, et al. (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Yogosawa S, Kawasaki M, Wakatsuki S, et al. (2006). "Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.". Biochem. Biophys. Res. Commun. 350 (1): 82–90. doi:10.1016/j.bbrc.2006.09.013. PMID 16996030.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
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