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Charged multivesicular body protein 3
Protein VPS24 PDB 2gd5.png
PDB rendering based on 2gd5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CHMP3 ; NEDF; VPS24
External IDs OMIM610052 MGI1913950 HomoloGene6368 GeneCards: CHMP3 Gene
RNA expression pattern
PBB GE VPS24 217837 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51652 66700
Ensembl ENSG00000115561 ENSMUSG00000053119
UniProt Q9Y3E7 Q9CQ10
RefSeq (mRNA) NM_001005753 NM_025783
RefSeq (protein) NP_001005753 NP_080059
Location (UCSC) Chr 2:
86.73 – 86.95 Mb
Chr 6:
71.54 – 71.58 Mb
PubMed search [1] [2]

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[1][2][3]


This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]


VPS24 has been shown to interact with IGFBP7.[1]


  1. ^ a b Wilson EM, Oh Y, Hwa V, Rosenfeld RG (Sep 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J Clin Endocrinol Metab 86 (9): 4504–11. doi:10.1210/jc.86.9.4504. PMID 11549700. 
  2. ^ Whitley P, Reaves BJ, Hashimoto M, Riley AM, Potter BV, Holman GD (Sep 2003). "Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization". J Biol Chem 278 (40): 38786–95. doi:10.1074/jbc.M306864200. PMID 12878588. 
  3. ^ a b "Entrez Gene: VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae)". 

Further reading[edit]