VPS29

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Vacuolar protein sorting 29 homolog (S. cerevisiae)
Protein VPS29 PDB 1w24.png
PDB rendering based on 1w24.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols VPS29 ; DC15; PEP11
External IDs OMIM606932 MGI1928344 HomoloGene9433 GeneCards: VPS29 Gene
EC number 3.1.3.3
Orthologs
Species Human Mouse
Entrez 51699 56433
Ensembl ENSG00000111237 ENSMUSG00000029462
UniProt Q9UBQ0 Q9QZ88
RefSeq (mRNA) NM_016226 NM_019780
RefSeq (protein) NP_057310 NP_062754
Location (UCSC) Chr 12:
110.93 – 110.94 Mb
Chr 5:
122.35 – 122.36 Mb
PubMed search [1] [2]

VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.[1]

Yeast homolog[edit]

The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae).[2]

Function[edit]

VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases.[3] The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.[4] Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene.[2]

References[edit]

  1. ^ Edgar AJ, Polak JM (November 2000). "Human homologues of yeast vacuolar protein sorting 29 and 35". Biochem. Biophys. Res. Commun. 277 (3): 622–30. doi:10.1006/bbrc.2000.3727. PMID 11062004. 
  2. ^ a b "Entrez Gene: VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae)". 
  3. ^ Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (December 2000). "Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes". Mol. Biol. Cell 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC 15060. PMID 11102511. 
  4. ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259. 

Further reading[edit]