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Vacuolar protein sorting 33 homolog B (yeast)
Symbols VPS33B ; FLJ14848
External IDs OMIM608552 MGI2446237 HomoloGene10261 GeneCards: VPS33B Gene
RNA expression pattern
PBB GE VPS33B 44111 at tn.png
PBB GE VPS33B 218415 at tn.png
More reference expression data
Species Human Mouse
Entrez 26276 233405
Ensembl ENSG00000184056 ENSMUSG00000030534
UniProt Q9H267 P59016
RefSeq (mRNA) NM_001289148 NM_178070
RefSeq (protein) NP_001276077 NP_835171
Location (UCSC) Chr 15:
91.54 – 91.57 Mb
Chr 7:
80.27 – 80.29 Mb
PubMed search [1] [2]

Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33B gene.[1][2]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[2]


  1. ^ Pevsner J, Hsu SC, Hyde PS, Scheller RH (Feb 1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene 183 (1-2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080. 
  2. ^ a b "Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast)". 

Further reading[edit]