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Vacuolar protein sorting 4 homolog A (S. cerevisiae)
Protein VPS4A PDB 1yxr.png
PDB rendering based on 1yxr.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VPS4A ; SKD1; SKD1A; SKD2; VPS4; VPS4-1
External IDs OMIM609982 MGI1890520 HomoloGene69132 GeneCards: VPS4A Gene
EC number
RNA expression pattern
PBB GE VPS4A 217913 at tn.png
More reference expression data
Species Human Mouse
Entrez 27183 116733
Ensembl ENSG00000132612 ENSMUSG00000031913
UniProt Q9UN37 Q8VEJ9
RefSeq (mRNA) NM_013245 NM_126165
RefSeq (protein) NP_037377 NP_569053
Location (UCSC) Chr 16:
69.35 – 69.36 Mb
Chr 8:
107.03 – 107.05 Mb
PubMed search [1] [2]

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.[1][2][3]


The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.[3]


VPS4A has been shown to interact with CHMP1A.[4]


  1. ^ Bishop N, Woodman P (April 2000). "ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking". Mol Biol Cell 11 (1): 227–39. doi:10.1091/mbc.11.1.227. PMC 14770. PMID 10637304. 
  2. ^ Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF et al. (September 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910. 
  3. ^ a b "Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)". 
  4. ^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell. Sci. 114 (Pt 13): 2395–404. PMID 11559748. 

Further reading[edit]