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Vacuolar protein sorting 4 homolog B (S. cerevisiae)
Protein VPS4B PDB 1wr0.png
PDB rendering based on 1wr0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VPS4B ; SKD1; SKD1B; VPS4-2
External IDs OMIM609983 MGI1100499 HomoloGene37976 GeneCards: VPS4B Gene
EC number
RNA expression pattern
PBB GE VPS4B 218171 at tn.png
More reference expression data
Species Human Mouse
Entrez 9525 20479
Ensembl ENSG00000119541 ENSMUSG00000009907
UniProt O75351 P46467
RefSeq (mRNA) NM_004869 NM_009190
RefSeq (protein) NP_004860 NP_033216
Location (UCSC) Chr 18:
61.06 – 61.09 Mb
Chr 1:
106.76 – 106.8 Mb
PubMed search [1] [2]

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.[1][2]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.[2]


  1. ^ Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910. 
  2. ^ a b "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)". 

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