L-tryptophan—pyruvate aminotransferase

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L-tryptophan---pyruvate aminotransferase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

L-tryptophan---pyruvate aminotransferase (EC, TAA1 (gene), vt2 (gene)) is an enzyme with system name L-tryptophan:pyruvate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

L-tryptophan + pyruvate \rightleftharpoons indole-3-pyruvate + L-alanine

This plant enzyme, along with EC, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.


  1. ^ Tao, Y., Ferrer, J.L., Ljung, K., Pojer, F., Hong, F., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Cheng, Y., Lim, J., Zhao, Y., Ballare, C.L., Sandberg, G., Noel, J.P. and Chory, J. (2008). "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants". Cell 133: 164–176. doi:10.1016/j.cell.2008.01.049. PMID 18394996. 
  2. ^ Mashiguchi, K., Tanaka, K., Sakai, T., Sugawara, S., Kawaide, H., Natsume, M., Hanada, A., Yaeno, T., Shirasu, K., Yao, H., McSteen, P., Zhao, Y., Hayashi, K., Kamiya, Y. and Kasahara, H. (2011). "The main auxin biosynthesis pathway in Arabidopsis". Proc. Natl. Acad. Sci. USA 108: 18512–18517. doi:10.1073/pnas.1108434108. PMC 3215075. PMID 22025724. 
  3. ^ Phillips, K.A., Skirpan, A.L., Liu, X., Christensen, A., Slewinski, T.L., Hudson, C., Barazesh, S., Cohen, J.D., Malcomber, S. and McSteen, P. (2011). "vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize". Plant Cell 23: 550–566. doi:10.1105/tpc.110.075267. PMID 21335375. 
  4. ^ Zhao, Y. (2012). "Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants". Mol. Plant 5: 334–338. doi:10.1093/mp/ssr104. PMC 3309920. PMID 22155950. 

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