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V-set domain containing T cell activation inhibitor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VTCN1 ; B7-H4; B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1
External IDs OMIM608162 MGI3039619 HomoloGene11627 GeneCards: VTCN1 Gene
RNA expression pattern
PBB GE VTCN1 219768 at tn.png
More reference expression data
Species Human Mouse
Entrez 79679 242122
Ensembl ENSG00000134258 ENSMUSG00000051076
UniProt Q7Z7D3 Q7TSP5
RefSeq (mRNA) NM_001253849 NM_178594
RefSeq (protein) NP_001240778 NP_848709
Location (UCSC) Chr 1:
117.69 – 117.75 Mb
Chr 3:
100.83 – 100.9 Mb
PubMed search [1] [2]

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.[1][2][3]

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][3]


  1. ^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (Jun 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165. 
  2. ^ Prasad DV, Richards S, Mai XM, Dong C (Jun 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166. 
  3. ^ a b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1". 

Further reading[edit]