VTCN1

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V-set domain containing T cell activation inhibitor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols VTCN1 ; B7-H4; B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1
External IDs OMIM608162 MGI3039619 HomoloGene11627 GeneCards: VTCN1 Gene
RNA expression pattern
PBB GE VTCN1 219768 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79679 242122
Ensembl ENSG00000134258 ENSMUSG00000051076
UniProt Q7Z7D3 Q7TSP5
RefSeq (mRNA) NM_001253849 NM_178594
RefSeq (protein) NP_001240778 NP_848709
Location (UCSC) Chr 1:
117.69 – 117.75 Mb
Chr 3:
100.83 – 100.9 Mb
PubMed search [1] [2]

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.[1][2][3]

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][3]

References[edit]

  1. ^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (Jun 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165. 
  2. ^ Prasad DV, Richards S, Mai XM, Dong C (Jun 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166. 
  3. ^ a b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1". 

Further reading[edit]