VTI1A

VTI1A
Identifiers
Aliases	VTI1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2, vesicle transport through interaction with t-SNAREs 1A
External IDs	OMIM: 614316 MGI: 1855699 HomoloGene: 39963 GeneCards: VTI1A
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.2 Start 112,446,998 bp End 112,818,744 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 D2 Start 55,304,727 bp End 55,615,741 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon pancreatic ductal cell monocyte bone marrow cells corpus callosum blood islet of Langerhans thymus gastrocnemius muscle Top expressed in superior frontal gyrus medial dorsal nucleus proximal tubule secondary oocyte lip yolk sac cerebellar cortex medial geniculate nucleus parotid gland neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function SNAP receptor activity protein binding SNARE binding Cellular component integral component of membrane endosome Golgi apparatus membrane synaptic vesicle autophagosome neuronal cell body SNARE complex perinuclear region of cytoplasm neuron projection terminus cytoplasmic vesicle clathrin-coated vesicle trans-Golgi network membrane ER to Golgi transport vesicle membrane cytosol Golgi membrane late endosome membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process voluntary musculoskeletal movement autophagy retrograde transport, endosome to Golgi protein transport intracellular protein transport Golgi ribbon formation vesicle-mediated transport Golgi to vacuole transport vesicle fusion with Golgi apparatus intra-Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport protein targeting to vacuole Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143187 53611 Ensembl ENSG00000151532 ENSMUSG00000024983 UniProt Q96AJ9 O89116 RefSeq (mRNA) NM_145206 NM_001318203 NM_001318205 NM_001365710 NM_001365711 NM_001365712 NM_001365713 NM_001365714 NM_001293685 NM_001293686 NM_016862 NM_001360431 NM_001360432 RefSeq (protein) NP_001305132 NP_001305134 NP_660207 NP_001352639 NP_001352640 NP_001352641 NP_001352642 NP_001352643 NP_001280614 NP_001280615 NP_058558 NP_001347360 NP_001347361 Location (UCSC) Chr 10: 112.45 – 112.82 Mb Chr 19: 55.3 – 55.62 Mb PubMed search
Wikidata
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Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.

The protein encoded by the VTI1A gene is a vesicular-SNARE (v-SNARE) protein which is located in the membranes of target vesicle compartments.

Further reading

• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
• Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
• Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.