VUF-5681

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VUF-5681
VUF-5681.png
Identifiers
CAS number 768358-61-8 YesY
PubChem 10330240
ChemSpider 8505701 N
Jmol-3D images Image 1
Properties
Molecular formula C11H19N3
Molar mass 193.288
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.[1] However while VUF-5681 blocks the activity of more potent H3 agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]

References[edit]

  1. ^ Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. PMID 16769092
  2. ^ Baker, JG (2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC pharmacology 8: 9. doi:10.1186/1471-2210-8-9. PMC 2430196. PMID 18538007.