VUF-6002

From Wikipedia, the free encyclopedia
Jump to: navigation, search
VUF-6002
VUF-6002.png
Systematic (IUPAC) name
5-Chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-benzimidazole
Clinical data
Legal status ?
Identifiers
CAS number 869497-75-6 YesY
ATC code ?
PubChem CID 10446295
IUPHAR ligand 1277
Chemical data
Formula C13H15ClN4O 
Mol. mass 278.737 g/mol
 YesY (what is this?)  (verify)

VUF-6002 (JNJ 10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor.[1] It has antiinflammatory and analgesic effects in animal studies of acute inflammation.[2]

References[edit]

  1. ^ Zhang, M; Thurmond, RL; Dunford, PJ (2007). "The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders". Pharmacology & therapeutics 113 (3): 594–606. doi:10.1016/j.pharmthera.2006.11.008. PMID 17275092. 
  2. ^ Coruzzi, G; Adami, M; Guaita, E; De Esch, IJ; Leurs, R (2007). "Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation". European Journal of Pharmacology 563 (1–3): 240–4. doi:10.1016/j.ejphar.2007.02.026. PMID 17382315.