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Von Willebrand factor A domain containing 2
Symbols VWA2 ; AMACO; CCSP-2; NET42
External IDs MGI2684334 HomoloGene18238 GeneCards: VWA2 Gene
Species Human Mouse
Entrez 340706 240675
Ensembl ENSG00000165816 ENSMUSG00000025082
UniProt Q5GFL6 Q70UZ7
RefSeq (mRNA) NM_001272046 NM_172840
RefSeq (protein) NP_001258975 NP_766428
Location (UCSC) Chr 10:
116 – 116.05 Mb
Chr 19:
56.87 – 56.91 Mb
PubMed search [1] [2]

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO) is a protein that in humans is encoded by the VWA2 gene.[1][2]

AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.[2] AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.[3]

The function of this protein is not yet clear; however, it was found markedly induced in colon cancers [4] and may be useful diagnostic serum marker.


  1. ^ "Entrez Gene: von Willebrand factor A domain containing 2". 
  2. ^ a b Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". J. Biol. Chem. 278 (50): 50240–9. doi:10.1074/jbc.M307794200. PMID 14506275. 
  3. ^ Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (August 2009). "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biol. 28 (8): 456–62. doi:10.1016/j.matbio.2009.07.006. PMID 19651211. 
  4. ^ Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene 24 (4): 724–31. doi:10.1038/sj.onc.1208134. PMID 15580307. 

Further reading[edit]

  • Eller E, Vardi P, Daly MJ et al. (2004). "IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family.". Ann. N. Y. Acad. Sci. 1037 (1): 145–9. doi:10.1196/annals.1337.024. PMID 15699509. 
  • Gebauer JM, Müller S, Hanisch FG et al. (2008). "O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein).". J. Biol. Chem. 283 (26): 17846–54. doi:10.1074/jbc.M704820200. PMID 18434322. 

External links[edit]