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Systematic (IUPAC) name
2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate
Clinical data
AHFS/ Consumer Drug Information
MedlinePlus a611021
  • US: C (Risk not ruled out)
  • (Prescription only)
Pharmacokinetic data
Bioavailability Negligible
Protein binding >99%
Metabolism Negligible
Excretion In urine
56124-62-0 YesY
PubChem CID 454216
DrugBank DB00385 YesY
ChemSpider 399974 YesY
UNII 2C6NUM6878 YesY
Chemical data
Formula C34H36F3NO13
723.644 g/mol
 YesY (what is this?)  (verify)

Valrubicin (N-trifluoroacetyladriamycin-14-valerate, trade name Valstar) is a chemotherapy drug used to treat bladder cancer. Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder.

It was originally launched as Valstar in the U.S. in 1999 for intravesical therapy of Bacille Calmette-Guérin (BCG)-refractory carcinoma in situ of the urinary bladder in patients in whom cystectomy would be associated with unacceptable morbidity or mortality; however, it was voluntarily withdrawn in 2002 due to manufacturing issues.[1] Valstar was relaunched on September 3, 2009.[2]

Side effects[edit]


  1. ^ "Manufacturing Issues Remain for Indevus' Valstar", U.S. Food and Drug Administration News. The MQN Weekly Bulletin, Jan. 11, 2008
  2. ^ "Endo Pharmaceuticals launches VALSTAR for treating recurrent carcinoma in situ bladder tumors" (Press release). 2009-09-03. Retrieved 2009-11-26.