Vanilloids

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The vanilloids are compounds which possess a vanillyl group. They include vanillyl alcohol, vanillin, vanillic acid, acetovanillon, vanillylmandelic acid, homovanillic acid, capsaicin, etc. Isomers are the isovanilloids.

Structure of vanillyl alcohol Structure of Vanillin Structure of vanillic acid Structure of acetovanillon
vanillyl alcohol vanillin vanillic acid acetovanillon

A number of vanilloids, most notably capsaicin, bind to the transient receptor potential vanilloid type 1 (TRPV1) receptor, an ion channel which naturally responds to noxious stimuli such as high temperatures and acidic pH.[1] This action is responsible for the burning sensation experienced after eating spicy peppers.

Outside of the food industry, vanilloids such as nonivamide are used commercially in pepper spray formulations.

Other vanilloids which act at TRPV1 include resiniferatoxin and olvanil.

References[edit]

  1. ^ Pingle, SC; Matta, JA; Ahern, GP (2007). "Capsaicin receptor: TRPV1 a promiscuous TRP channel". Handbook of experimental pharmacology. Handbook of Experimental Pharmacology 179 (179): 155–171. doi:10.1007/978-3-540-34891-7_9. ISBN 978-3-540-34889-4. PMID 17217056. 

Literature[edit]