Small vessels like vasa vasorum and vasa nervorum are particularly susceptible to external mechanical compression. Vasa vasorum and a decrease in blood flow through the vasa nervorum has been implicated in the development of diabetic neuropathy. Arteritis of the vasa nervorum leads to mononeuritis multiplex or polyneuropathy. Occlusion of vasa nervosum at level of epineurial arterioles leads to ischemia of nerves leading to vasculitic neuropathy. and has been implicated as cause in few cases of facial nerve paralysis. During invasive diagnostic or therapeutic procedures, injecting a vasoconstrictor close to nerve can reduce perfusion to its supplying vessel, risking ischemic nerve injury.
^ abClinically oriented anatomy (6th ed., [International ed.]. ed.). Philadelphia [etc.]: Lippincott Williams & Wilkins, Wolters Kluwer. 2010. p. 50. ISBN9781605476520.
^ abcHellmann, [edited by] John B. Imboden, John H. Stone, David B. (2007). Current rheumatology diagnosis & treatment (2nd ed. ed.). New York ; Toronto: Lange Medical Books/McGraw-Hill, Medical Pub. Division. ISBN9780071460408.