Vascular endothelial growth factor C

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Vascular endothelial growth factor C
Protein VEGFC PDB 2X1W.png
Rendering based on PDB 2X1W.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VEGFC ; Flt4-L; VRP
External IDs OMIM601528 MGI109124 HomoloGene3962 GeneCards: VEGFC Gene
RNA expression pattern
PBB GE VEGFC 209946 at tn.png
More reference expression data
Species Human Mouse
Entrez 7424 22341
Ensembl ENSG00000150630 ENSMUSG00000031520
UniProt P49767 P97953
RefSeq (mRNA) NM_005429 NM_009506
RefSeq (protein) NP_005420 NP_033532
Location (UCSC) Chr 4:
177.6 – 177.71 Mb
Chr 8:
54.08 – 54.19 Mb
PubMed search [1] [2]

Vascular endothelial growth factor C is a VEGF. The human gene encoding it is VEGFC.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis [1] and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D).[2]

Mutations in VEGFC cause Milroy disease .Balboa-Beltran, E; Fernández-Seara, M. J.; Pérez-Muñuzuri, A; Lago, R; García-Magán, C; Couce, M. L.; Sobrino, B; Amigo, J; Carracedo, A; Barros, F (2014). "A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease". Journal of Medical Genetics 51 (7): 475–8. doi:10.1136/jmedgenet-2013-102020. PMID 24744435.  edit

Pathological VEGF-C Expression[edit]

Lymphedema is caused by an imbalance between lymphatic vessel formation and absorption. Experimentally this can be created by overexpression of VEGF-C Lymphangioma: Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.


Further reading[edit]