Vascular endothelial growth factor C

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Vascular endothelial growth factor C
Protein VEGFC PDB 2X1W.png
Rendering based on PDB 2X1W.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols VEGFC ; Flt4-L; VRP
External IDs OMIM601528 MGI109124 HomoloGene3962 GeneCards: VEGFC Gene
RNA expression pattern
PBB GE VEGFC 209946 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7424 22341
Ensembl ENSG00000150630 ENSMUSG00000031520
UniProt P49767 P97953
RefSeq (mRNA) NM_005429 NM_009506
RefSeq (protein) NP_005420 NP_033532
Location (UCSC) Chr 4:
177.6 – 177.71 Mb
Chr 8:
54.08 – 54.19 Mb
PubMed search [1] [2]

Vascular endothelial growth factor C is a VEGF. The human gene encoding it is VEGFC.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis [1] and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D).[2]

Mutations in VEGFC cause Milroy disease .Balboa-Beltran, E; Fernández-Seara, M. J.; Pérez-Muñuzuri, A; Lago, R; García-Magán, C; Couce, M. L.; Sobrino, B; Amigo, J; Carracedo, A; Barros, F (2014). "A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease". Journal of Medical Genetics 51 (7): 475–8. doi:10.1136/jmedgenet-2013-102020. PMID 24744435.  edit

Pathological VEGF-C Expression[edit]

Lymphedema is caused by an imbalance between lymphatic vessel formation and absorption. Experimentally this can be created by overexpression of VEGF-C Lymphangioma: Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

References[edit]

Further reading[edit]