Vasoplegic syndrome

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Vasoplegic syndrome (VPS) is a postperfusion syndrome characterized low systemic vascular resistance and a high cardiac output.

Definition[edit]

Vasoplegic syndrome is defined as low systemic vascular resistance ( SVR index <1,600 dyn∙seg/cm5/m2 ) and high cardiac output ( cardiac index >2.5 l/min/m2 ) within the first 4 postoperative hours.[1]

Causes[edit]

VPS occurs more frequently after on pump CABG surgery verses off pump CABG surgery.[2] Hypothermia during surgery may also increase ones risk of developing VPS post operatively.[3]

Treatment[edit]

There is some evidence to support the use of methylene blue in the treatment of this condition.[4][5]

Epidemiology[edit]

One case series reports a rate of 1 in 120 cases.[6]

References[edit]

  1. ^ "Critical Care | Full text | Vasoplegic syndrome after cardiopulmonary bypass surgery – associated factors and clinical outcomes: a nested case-control study". 
  2. ^ Sun X, Zhang L, Hill PC, et al. (October 2008). "Is incidence of postoperative vasoplegic syndrome different between off-pump and on-pump coronary artery bypass grafting surgery?". Eur J Cardiothorac Surg 34 (4): 820–5. doi:10.1016/j.ejcts.2008.07.012. PMID 18715792. 
  3. ^ Xu J, Long C, Qi R, Xie L, Shi S, Zhang Y (January 2002). "[Study of mechanism of vasoplegic syndrome for open heart surgery]". Zhonghua Yi Xue Za Zhi (in Chinese) 82 (2): 127–30. PMID 11953144. 
  4. ^ "BestBets: Is Methylene Blue of benefit in treating adult patients who develop vasoplegic syndrome during Cardiac Surgery". 
  5. ^ Stawicki SP, Sims C, Sarani B, Grossman MD, Gracias VH (May 2008). "Methylene blue and vasoplegia: who, when, and how?". Mini Rev Med Chem 8 (5): 472–90. doi:10.2174/138955708784223477. PMID 18473936. 
  6. ^ Gomes WJ, Carvalho AC, Palma JH, Gonçalves Júnior I, Buffolo E (1994). "[Vasoplegic syndrome: a new dilemma]". Rev Assoc Med Bras 40 (4): 304. PMID 7633508.