The Verbandsliga Hessen-Süd is fed by the Gruppenliga Hessen-Darmstadt, Hessen-Frankfurt West and Hessen-Frankfurt Ost. The winners of those are automatically promoted to the Verbandsliga, the runners-up play-off for another promotion spot.
Two Bavarian clubs play within the area of the Verbandsliga Süd. FC Bayern Alzenau and Viktoria Aschaffenburg have played in this league in the past. In 1992, FC Bayern Alzenau switched leagues, coming from the Landesliga Bayern-Nord straight across to the Verbandsliga Hessen-Süd and now, having been promoted, play in the Hessenliga. Viktoria Aschaffenburg have previously been promoted too, but as of the 2010–11 season will play in the Verbandsliga again.
Up until 1973 it was common for teams to move between Landesligen, resulting in the fact that some teams have won titles in two different Landesligen. This practice has since stopped.
Along with the renaming of the Oberliga Hessen to Hessenliga in 2008, the Landesliga was renamed Verbandsliga Hessen-Süd.
Four clubs have won the league three times each, Rot-Weiss Frankfurt, SpVgg 05 Bad Homburg, SC Viktoria 06 Griesheim and SG Egelsbach. However, SpVgg 05 Bad Homburg has also won the Landesliga Mitte in 1972, making it four Landesliga titles.
Like SpVgg 05 Bad Homburg, FC Hanau 93, SV Wiesbaden and Kickers Offenbach II have also won titles in the Landesliga Süd and Mitte.