|Drawing of colon seen from front
(appendix coloured red)
|Arteries of cecum and appendix (appendix labeled as vermiform process at lower right)|
|Gray's||subject #249 1178|
The appendix (or vermiform appendix; also cecal [or caecal] appendix; also vermix) is a blind-ended tube connected to the cecum, from which it develops embryologically. The cecum is a pouchlike structure of the colon. The appendix is located near the junction of the small intestine and the large intestine.
Size and location 
The human appendix averages 11 cm in length but can range from 2 to 20 cm. The diameter of the appendix is usually between 7 and 8 mm. The longest appendix ever removed measured 26 cm from a patient in Zagreb, Croatia. The appendix is located in the right lower quadrant of the abdomen, near the right hip bone. Its position within the abdomen corresponds to a point on the surface known as McBurney's point (see below). While the base of the appendix is at a fairly constant location, 2 cm below the ileocecal valve, the location of the tip of the appendix can vary from being retrocecal (behind the cecum) (74%) to being in the pelvis to being extraperitoneal.
The human appendix has been proposed to be a vestigial structure, a structure that has lost all or most of its original function through the process of evolution. The vermiform appendix has been proposed to be the shrunken remainder of the cecum that was found in a remote ancestor of humans, but a 2013 study refutes the idea of an inverse relationship between cecum size and appendix size and presence. Ceca, which are found in the digestive tracts of many extant herbivores, house mutualistic bacteria which help animals digest the cellulose molecules that are found in plants.
Immune function 
Loren G. Martin, a professor of physiology at Oklahoma State University, argues that the appendix has a function in fetuses and adults. Endocrine cells have been found in the appendix of 11-week-old fetuses that contribute to "biological control (homeostatic) mechanisms." In adults, Martin argues that the appendix acts as a lymphatic organ. The appendix is experimentally verified as being rich in infection-fighting lymphoid cells, suggesting that it might play a role in the immune system. Zahid suggests that it plays a role in both manufacturing hormones in fetal development as well as functioning to "train" the immune system, exposing the body to antigens so that it can produce antibodies. In 2004, he noted that doctors in the previous decade had stopped removing the appendix during other surgical procedures as a routine precaution, because it can be successfully transplanted into the urinary tract to rebuild a sphincter muscle and reconstruct a functional bladder.
Maintaining gut flora 
Although it was long accepted that the immune tissue, called gut associated lymphoid tissue, surrounding the appendix and elsewhere in the gut carries out a number of important functions, explanations were lacking for the distinctive shape of the appendix and its apparent lack of importance as judged by an absence of side effects following appendectomy.
William Parker, Randy Bollinger, and colleagues at Duke University proposed that the appendix serves as a haven for useful bacteria when illness flushes those bacteria from the rest of the intestines. This proposal is based on a new understanding of how the immune system supports the growth of beneficial intestinal bacteria, in combination with many well-known features of the appendix, including its architecture, its location just below the normal one-way flow of food and germs in the large intestine, and its association with copious amounts of immune tissue. Research performed at Winthrop University-Hospital showed that individuals without an appendix were four times more likely to have a recurrence of Clostridium difficile. However, other research showed that there is a greater rate of C. difficile infection among people with an appendix than those without.
A possible scenario for the progression from a fully functional cecum to the current human appendix was put forth by Charles Darwin. He suggested that the appendix was used for digesting leaves as primates. It may be a vestigial organ of ancient humans that has degraded to nearly nothing over the course of evolution. The very long cecum of some herbivorous animals, such as found in the horse or the koala, appears to support this theory. The koala's cecum enables it to host bacteria that specifically help to break down cellulose. Human ancestors may have also relied upon this system when they lived on a diet rich in foliage. As people began to eat more easily digested foods, they may have become less reliant on cellulose-rich plants for energy. As the cecum became less necessary for digestion, mutations that were previously deleterious (and would have hindered evolutionary progress) were no longer important, so the mutations have survived. It's suggested that these alleles became more frequent and the cecum continued to shrink. After millions of years, the once-necessary cecum degraded to be the appendix of today.
Dr. Heather F. Smith of Arizona State University explained:
Recently improved understanding of gut immunity has merged with current thinking in biological and medical science, pointing to an apparent function of the mammalian cecal appendix as a safe-house for symbiotic gut microbes, preserving the flora during times of gastrointestinal infection in societies without modern medicine. This function is potentially a selective force for the evolution and maintenance of the appendix. Three morphotypes of cecal-appendices can be described among mammals based primarily on the shape of the cecum: a distinct appendix branching from a rounded or sac-like cecum (as in many primate species),an appendix located at the apex of a long and voluminous cecum (as in the rabbit, greater glider and Cape dune mole rat), and an appendix in the absence of a pronounced cecum (as in the wombat). In addition, long narrow appendix-like structures are found in mammals that either lack an apparent cecum (as in monotremes) or lack a distinct junction between the cecum and appendix- like structure (as in the koala). A cecal appendix has evolved independently at least twice, and apparently represents yet another example of convergence in morphology between Australian marsupials and placentals in the rest of the world. Although the appendix has apparently been lost by numerous species, it has also been maintained for more than 80 million years in at least one clade.
In a more recent paper, the appendix was found to have evolved at least 32 times (and perhaps as many as 38 times) and to have been lost no more than six times. This suggests that the cecal appendix has a selective advantage in many situations and argues strongly against its vestigial nature. This complex evolutionary history of the appendix, along with a great heterogeneity in its evolutionary rate in various taxa, suggests that it is a recurrent trait.
Such a function may be useful in a culture lacking modern sanitation and healthcare practice, where diarrhea may be prevalent. Current epidemiological data on the cause of death in developed countries collected by the World Health Organization in 2001 show that acute diarrhea is now the fourth leading cause of disease-related death in developing countries (data summarized by The Bill and Melinda Gates Foundation). Two of the other leading causes of death are expected to have exerted limited or no selection pressure.
||This section needs additional citations for verification. (April 2007)|
The most common diseases of the appendix (in humans) are appendicitis and carcinoid tumors (appendiceal carcinoid). Appendix cancer accounts for about 1 in 200 of all gastrointestinal malignancies. In rare cases, adenomas are also present.
Appendicitis (or epityphlitis) is a condition characterized by inflammation of the appendix. Pain often begins in the center of the abdomen, corresponding to the appendix's development as part of the embryonic midgut. This pain is typically a dull, poorly localized, visceral pain.
As the inflammation progresses, the pain begins to localize more clearly to the right lower quadrant, as the peritoneum becomes inflamed. This peritoneal inflammation, or peritonitis, results in rebound tenderness (pain upon removal of pressure rather than application of pressure). In particular, it presents at McBurney's point, 1/3 of the way along a line drawn from the anterior superior iliac spine to the umbilicus. Typically, point (skin) pain is not present until the parietal peritoneum is inflamed, as well. Fever and an immune system response are also characteristic of appendicitis.
Appendicitis requires removal of the inflamed appendix, either by laparotomy or laparoscopy. Untreated, the appendix may rupture, leading to peritonitis, followed by shock, and, if still untreated, death.
The surgical removal of the vermiform appendix is called an appendectomy, or appendicectomy. This removal is normally performed as an emergency procedure when the patient is suffering from acute appendicitis. In the absence of surgical facilities, intravenous antibiotics are used to delay or avoid the onset of sepsis. In some cases, the appendicitis resolves completely; more often, an inflammatory mass forms around the appendix. This is a relative contraindication to surgery.
Other uses 
The appendix is also used as a means to access the colon in children with paralysed bowels or major rectal sphincter problems. The appendix is brought out to the skin surface and the child/parent can then attach a catheter and easily wash out the colon (via normal defaecation) using an appropriate solution.
- Smith H. F., Fisher R. E., Everett M. L., Thomas A. D., Bollinger, R. R., Parker W. (2009). "Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix". Journal of Evolutionary Biology 22: 1984–1999. doi:10.1111/j.1420-9101.2009.01809.x. PMID 19678866.
- Smith H. F., Parker W., Kotzé, S. H., Laurin, M. (2013). "Multiple independent appearances of the cecal appendix in mammalian evolution and an investigation of related ecological and anatomical factors". Comptes rendus Palevol. doi:10.1016/j.crpv.2012.12.001.
- "Guinness world record for longest appendix removed". Guinnessworldrecords.com. Retrieved 2011-10-03.
- Paterson-Brown, S. (2007). "15. The acute abdomen and intestinal obstruction". In Parks, Rowan W.; Garden, O. James; Carter, David John; Bradbury, Andrew W.; Forsythe, John L. R. Principles and practice of surgery (5th ed.). Edinburgh: Churchill Livingstone. ISBN 0-443-10157-4.
- "Animal Structure & Function". Sci.waikato.ac.nz. Retrieved 2011-10-03.
- "What is the function of the human appendix? Did it once have a purpose that has since been lost?". Scientific American. 1999-10-21. Retrieved 2008-07-01.
- Zahid, A. (April 2004). "The vermiform appendix: not a useless organ". J Coll Physicians Surg Pak 14 (4): 256–8. PMID 15228837.
- Kumar, Vinay; Robbins, Stanley L.; Cotran, Ramzi S. (1989). Robbins' pathologic basis of disease (4th ed.). Philadelphia: Saunders. pp. 902–3. ISBN 0-7216-2302-6.
- Associated Press. "Scientists may have found appendix's purpose". MSNBC, 5 October 2007. Accessed 17 March 2009.
- Bollinger, R.R.; Barbas, A.S.; Bush, E.L.; Lin, S.S. & Parker. W. (21 December 2007). "Biofilms in the large bowel suggest an apparent function of the human vermiform appendix". Journal of Theoretical Biology 249 (4): 826–831. doi:10.1016/j.jtbi.2007.08.032. ISSN 0022-5193. PMID 17936308.
- Sonnenburg J.L., Angenent L.T., Gordon J.I. (June 2004). "Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?". Nat. Immunol. 5 (6): 569–73. doi:10.1038/ni1079. PMID 15164016.
- Everett M.L., Palestrant D., Miller S.E., Bollinger R.R., Parker W. (2004). "Immune exclusion and immune inclusion: a new model of host-bacterial interactions in the gut". Clinical and Applied Immunology Reviews 5: 321–32.
- Merchant, R.; Mower, W.R.; Ourian, A.; Abrahamian, M.F.; Moran G.J.; Krishnadasan, A.; Talan, D.A.. (17 January 2012). "Association Between Appendectomy and Clostridium difficile Infection". J Clin Med Res 4 (1): 17–19. doi:10.4021/jocmr770w. PMC 3279496. PMID 22383922.
- Darwin, Charles (1871) "Jim's Jesus". The Descent of Man, and Selection in Relation to Sex. John Murray: London.
- Laurin M., Everett, M.L. Parker W. (2011). "The cecal appendix: one more immune component with a function disturbed by post-industrial culture". Anatomical Record 294 (4): 567–579. doi:10.1002/ar.21357.
- Needs Citation
- Evolution of the Appendix: A Biological 'Remenant' No More; By Duke Medicine News and Communications; Published: Aug. 20, 2009 Updated: Aug. 21, 2009, http://www.dukehealth.org/health_library/news/evolution_of_the_appendix_a_biological_remnant_no_more
- "Appendix disorders Symptoms, Diagnosis, Treatments and Causes". Wrongdiagnosis.com. Retrieved 2010-05-19.
- "Statistics about Appendix disorder". Wrongdiagnosis.com. Retrieved 2010-05-19.
- Miller R., Kenneth; Levine, Joseph (2002). Biology. Prentice Hall. pp. 92–98. ISBN 0-13-050730-X.
- "appendicectomy - definition of appendicectomy". Farlex Incorporation.
- Mingin G.C., Baskin L.S. (2003). "Surgical management of the neurogenic bladder and bowel". Int Braz J Urol 29 (1): 53–61. doi:10.1590/S1677-55382003000100012. PMID 15745470.
Further reading 
- "The vestigiality of the human vermiform appendix: A Modern Reappraisal"—evolutionary biology argument that the appendix is vestigial
- Appendix May Actually Have a Purpose—2007 WebMD article
- Smith, H.F.; R.E. Fisher, M.L. Everett, A.D. Thomas, R. Randal Bollinger, and W. Parker (October 2009). "Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix". Journal of Evolutionary Biology 22 (10): 1984–99. doi:10.1111/j.1420-9101.2009.01809.x. ISSN 1420-9101. PMID 19678866.
- Cho, Jinny. "Scientists refute Darwin's theory on appendix". The Chronicle (Duke University), August 27, 2009. (News article on the above journal article.)
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