DNA studies have shown that any relation to HPV is purely coincidental (as a high percentage of the sexually active population has or has had HPV). Vestibular papillomatosis is not transmittable or pathological. HPV will turn white upon a vinegar application test, and Vestibular pallimatosis will not. Additionally, HPV occurs in cauliflower-like clusters at the base whereas Vestibular papillomatosis does not. It cannot be sexually transmitted. Most women have no symptoms with the growth; however, some report itching, stinging, burning, and pain where the growths appear, and the symptoms are often misdiagnosed as a yeast infection. Unlike yeast infections, there is discharge associated with Vestibular papillomatosis. The condition is sometimes referred to as squamous papillomatosis.
There is some evidence that (VP) may be congenital; however, these cases are extremely rare.