Originally a series of unformed tracks linking pastoral holdings, the route was developed as a gravel road in the 1950s to aid the beef industry. Improvements took place in the 1960s which tied in with the development of the Ord Irrigation Scheme, which enabled the introduction of road trains. It was designated as National Highway in 1974 and was fully reconstructed and sealed to a good standard by the early 1990s. The highway serves pastoral, mining and tourism industries, as well as the Ord Irrigation Scheme agricultural development near Kununurra.
The highway is described as spectacular, with escarpment ranges, the unique boab trees and the mighty Victoria River that runs into deep valleys and spectacular gorges. Its eastern terminus is at Katherine which is renowned for Katherine Gorge. In Western Australia, the access road to the Ord River Dam which holds back Lake Argyle - Australia's largest artificial lake - begins at the Victoria Highway just west of the Western Australia / Northern Territory border. The western terminus is at Great Northern Highway, south of Whyndham.
The highway crosses Victoria River near Timber Creek, and this crossing is particularly flood-prone in the wet season. Water overtopping the bridge can cut the main Western Australia - Northern Territory link for days or even weeks during the November - April rainy period. It is not unheard of for the bridge surface to at times be submerged below 10 metres of floodwaters.