The Line 2 platforms opened on 21 January 1903, although trains had been operating between Étoile and Anvers since 7 October 1902. On 19 October 1904, it became the terminus for the first section of line 3, the other terminus being Père Lachaise. When first built, the platforms for line 3 were parallel and at the same height as those for line 2. However, for the extension to Porte de Champerret, the line 3 platforms and tracks had to be lowered in order for trains to be able to pass underneath the line 2 tracks.
It is named after the Avenue de Villiers, which once led the 18th century village of Villiers-la-Garenne, now part of Levallois-Perret. The Barrière de Monceau, a gate built for the collection of taxation as part of the Wall of the Farmers-General was at the same location; the gate was built between 1784 and 1788 and demolished after 1859.