Villitis of unknown etiology

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Villitis of unknown etiology
Classification and external resources
Villitis of unknown etiology - very high mag.jpg
Micrograph of villitis of unknown etiology. H&E stain.

Villitis of unknown etiology, abbreviated VUE, is an inflammatory process that involves the chorionic villi (villitis) those cause (etiology) is not known. VUE is associated with recurrent miscarriage and intrauterine growth restriction,[1] and recurs in subsequent pregnancies.[2]


Histomorphologically, VUE is characterized by a lymphocytic infiltrate of the chorionic villi without a demonstrable cause. Plasma cells should be absent; the presence of plasma cells suggests an infective etiology, e.g. CMV infection.

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  1. ^ Redline, RW. (Oct 2007). "Villitis of unknown etiology: noninfectious chronic villitis in the placenta.". Hum Pathol 38 (10): 1439–46. doi:10.1016/j.humpath.2007.05.025. PMID 17889674. 
  2. ^ Feeley L, Mooney EE (2010). "Villitis of unknown aetiology: correlation of recurrence with clinical outcome". J Obstet Gynaecol 30 (5): 476–9. doi:10.3109/01443611003802339. PMID 20604650.