Vinylacetyl-CoA Delta-isomerase

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vinylacetyl-CoA delta-isomerase
Identifiers
EC number 5.3.3.3
CAS number 9023-73-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a vinylacetyl-CoA Delta-isomerase (EC 5.3.3.3) is an enzyme that catalyzes the chemical reaction

vinylacetyl-CoA \rightleftharpoons crotonyl-CoA

Hence, this enzyme has one substrate, vinylacetyl-CoA, and one product, crotonyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is vinylacetyl-CoA Delta3-Delta2-isomerase. Other names in common use include vinylacetyl coenzyme A Delta-isomerase, vinylacetyl coenzyme A isomerase, and Delta3-cis-Delta2-trans-enoyl-CoA isomerase. This enzyme participates in butanoate metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U8V.

References[edit]

  • Lynen F, Knappe J, Lorch E, Jutting G and Ringelmann E (1959). "Die biochemische Funktion des Biotins". Angew. Chem. 71 (15–16): 481–486. doi:10.1002/ange.19590711503. 
  • Rilling HC and Coon MJ (1960). "The enzymatic isomerization of beta-methylvinylacetyl coenzyme A and the specificity of a bacterial beta-methylcrotonyl coenzyme A carboxylase". J. Biol. Chem. 235: 3087–3092.