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Virginia Avenue is a street in the Northwest, Southwest, and Southeast quadrants of Washington, D.C. Like other state-named streets in Washington, it diagonally crosses the grid pattern formed by lettered (east-west) and numbered (north-south) streets.
Many famous landmarks are adjacent to Virginia Avenue, including the Watergate complex, George Washington University's Hall on Virginia Avenue (which, formerly branded as a Howard Johnson's hotel, served as the lookout point for the Watergate break-in in 1972), the Pan-American Health Organization, the Harry S. Truman Building (Department of State headquarters), the Main Interior Building (Department of the Interior headquarters), the John F. Kennedy Center for the Performing Arts, and West Potomac Park.
The western terminus of Virginia Avenue NW is at the Rock Creek and Potomac Parkway. Virginia Avenue provides access from the Parkway to Interstate 66. The eastern terminus is at Constitution Avenue between 17th and 18th streets. Between those termini, there is a partial interchange with the E Street Expressway. Non-contiguous portions of Virginia Avenue are found in Southwest, paralleling the CSX railroad tracks, and Southeast, paralleling the Southeast Freeway.