Fox was born in Wheeling, West Virginia, the daughter of Marie (née Oglseby) and Frederick Fox. In 1924 she married film producerDarryl F. Zanuck, with whom she had three children, Darrylin Zanuck, Susan Zanuck, and Richard D. Zanuck. The couple separated in 1956 over the studio mogul's affairs with other women, though they were never legally divorced; but according to Zanuck biographers, she cared for him at their home from the time he became mentally incapacitated in the early 1970s until his death in 1979.
Despite some Internet accounts to the contrary, Virginia Fox was not related to William Fox, whose name is preserved in the company 20th Century Fox, which Darryl Zanuck created and led for decades. William Fox founded Fox Studios, but had lost control of it by the time Zanuck acquired it and merged it into his own empire.
Virginia Fox Zanuck's tomb in Westwood Memorial Park, Westwood, Los Angeles, California