The mountain range forms a portion of the drainage divide between the Truckee River (north) and the Carson River (south). Truckee Meadows and the Washoe Valley are to the west, and the Lahontan Valley is to the east.
For the notable 1860s silver strike and mining town in the Virginia Range, see:
- Comstock Lode
- Virginia City, Nevada
- Virginia City Historic District (Virginia City, Nevada)
- National Register of Historic Places in Storey County, Nevada
- "Boundary Descriptions and Names of Regions, Subregions, Accounting Units and Cataloging Units". USGS.gov. Retrieved 2010-10-21.