Virodene is a controversial AIDS drug developed in South Africa, but rejected by the scientific community. Controversy surrounds the research procedures, political interference and the safety and efficacy of the drug itself, the main active ingredient of which is the industrial solvent Dimethylformamide (DMF).
Michelle Olga Patricia Visser, working as a medical technician at Pretoria Hospital, says she discovered the anti-bacterial properties of DMF while conducting experiments to freeze animal hearts using this substance. In conjunction with her businessman husband, Jacques Siegfried "Zigi" Visser, she administered the drug to 11 patients without approval. They were rebuked for these actions and the South African Medicines Control Council blocked further human trials.
More human trials were conducted in Tanzania in 2000 even after the South African Medicines Control Council ruled that such trials would be unethical and in contravention of the law and refused permission for human trials in 1998. The Tanzania health agency, NIMR, also rejected proposals for human trials, but the Vissers approached the Tanzanian Defence Force directly and conducted the trials in military hospitals.
Olga Visser claimed she was a full professor and head of the department of New Technologies in Medicine at Moderna University in Lisbon, Portugal, but officials insist there is no record of her on the faculty or even of such a department.
On several occasions the Vissers conducted human trials without any authorisation from the appropriate health authorities.
In 1997 the researchers were allowed to make presentations to the South African Cabinet. They received support from Thabo Mbeki, then South African deputy president and Nkosazana Dlamini-Zuma, the health minister at the time. Mbeki even criticised the Medicines Control Council, stating that "it became more and more difficult to understand the attitude adopted by the MCC" and that "I and many others will not rest until the efficacy or otherwise of Virodene is established scientifically" in direct opposition to the rejection of human trials by the Medicines Control Council.
In the same letter Mbeki went as far as suggesting that parties who caused the controversy surrounding Virodene wanted to create the AIDS pandemic in Sub-Saharan Africa:
Two thirds of those affected world-wide are in Sub-Saharan Africa, including a 2,8 million strong South African contingent. Often I have wondered whether those who have generated sand storms with the greatest enthusiasm, did not, in fact, seek to achieve precisely this result!—Thabo Mbeki, 
Some analysts point out that the mere involvement of senior government officials in a regulatory process for which there exists well established regulatory bodies such as the Medicines Control Council could only ever serve to open up the process to charges of maladministration.
Maisela was on Mbeki's "consultative council" during Mbeki's tenure as Deputy President and at the time of the investments headed Negotiated Benefits Consultants (NBC) which was owned by Worldwide Africa Holdings a company co-founded by Wiseman Nkhuhlu, then presidential advisor to Mbeki.
Reports alleging investment from source close to government again surface in 2007. The fresh reports by the newspaper The Saturday Star suggested investments between 2000 and 2001 that tapered off after the trials in Tanzania were aborted, allegations denied by the Presidency.
Alcor Life Extension Foundation
Initial funding came from the controversial cryonics (low temperature preservation of humans after death) company Alcor Life. The funding came because of the main Virodene founder's research into the freezing and thawing of animal hearts.
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- Mulholland, Stephen (1998). "Virodene saga a lesson in how not to conduct affairs". Business Times (Sunday Times (South Africa)). Retrieved 2007-09-27.
- "Who's bankrolling Virodene?". Mail & Guardian. 2002-06-22. Retrieved 2007-09-27.
- "Govt slams Virodene story". 24.com (Media24). 2007-09-15. Retrieved 2007-09-27.