Viroplasm
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A viroplasm is an inclusion body in a cell where viral replication/assembly occurs. They may be thought of as viral factories in the cell. Very little is understood about the mechanism of viroplasm formation. These appear electron-dense under the electron microscope, most likely due to high amounts of viral RNA in them.
Viroplasm has been found in the cauliflower mosaic virus,[1] rotavirus,[2] vaccinia virus[3] and the rice dwarf virus.[4]
[edit] References
- ^ Xiong; Muller, S; Lebeurier, G; Hirth, L (1982). "Identification by immunoprecipitation of cauliflower mosaic virus in vitro major translation product with a specific serum against viroplasm protein". The EMBO journal 1 (8): 971–976. PMC 553144. PMID 16453427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553144.
- ^ Nilsson; Von Bonsdorff, CH; Weclewicz, K; Cohen, J; Svensson, L (1998). "Assembly of viroplasm and virus-like particles of rotavirus by a Semliki Forest virus replicon". Virology 242 (2): 255–65. doi:10.1006/viro.1997.8987. PMID 9514960.
- ^ Szajner; Weisberg, AS; Wolffe, EJ; Moss, B (2001). "Vaccinia virus A30L protein is required for association of viral membranes with dense viroplasm to form immature virions". Journal of virology 75 (13): 5752–61. doi:10.1128/JVI.75.13.5752-5761.2001. PMC 114291. PMID 11390577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=114291.
- ^ Wei; Kikuchi, A; Suzuki, N; Shimizu, T; Hagiwara, K; Chen, H; Omura, T (2006). "Pns4 of rice dwarf virus is a phosphoprotein, is localized around the viroplasm matrix, and forms minitubules". Archives of Virology 151 (9): 1701–12. doi:10.1007/s00705-006-0757-4. PMID 16609816.
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