The club was founded in 1914 as Foot-Ball Club Entella and went bankrupt in 2001.
It was refounded in 2002 as Unione Sportiva Valle Sturla Entella.
In summer 2010 it was renamed with its current name, after having been admitted in Lega Pro Seconda Divisione. In summer 2012, Virtus Entella was promoted, for the first time, to Lega Pro Prima Divisione by repechange to fill the vacancies created. They completed the 2012–13 season in style, taking part to the promotion playoff, where they were defeated by Lecce in the semi-finals.
In the 2013–14 season, Virtus Entella took part to the Girone A of the Italian third tier, and topped the league for most of the season. On 4 May 2014, a 2–1 away win at Cremonese in the final day of the season ensured Virtus Entella the league championship title and a spot in the 2014–15 Serie B, in what will be the club's first appearance ever in the Italian second tier.