Vitamin-K-epoxide reductase (warfarin-sensitive)

vitamin-K-epoxide reductase (warfarin-sensitive)
Identifiers
EC number	1.1.4.1
CAS number	55963-40-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a vitamin-K-epoxide reductase (warfarin-sensitive) (EC 1.1.4.1) is an enzyme that catalyzes the chemical reaction

2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol $\rightleftharpoons$ 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Thus, the two substrates of this enzyme are 2-methyl-3-phytyl-1,4-naphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase. This enzyme participates in biosynthesis of steroids. At least one compound, Warfarin is known to inhibit this enzyme.

References

• Lee JJ, Fasco MJ (1984). "Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide". Biochemistry. 23 (10): 2246–52. doi:10.1021/bi00305a024. PMID 6733086. 
• Mukharji I, Silverman RB (1985). "Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone". Proc. Natl. Acad. Sci. U. S. A. 82 (9): 2713–7. doi:10.1073/pnas.82.9.2713. PMC 397635. PMID 3857611. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=397635. 
• Whitlon DS, Sadowski JA, Suttie JW (1978). "Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition". Biochemistry. 17 (8): 1371–7. doi:10.1021/bi00601a003. PMID 646989.