Vitrification (from Latin vitreum, "glass" via French vitrifier) is the transformation of a substance into a glass. Usually, it is achieved by rapidly cooling a liquid through the glass transition. Certain chemical reactions also result in glasses. An important application is the vitrification of an antifreeze-like liquid in cryopreservation.
Vitrification is characteristic for amorphous materials or disordered systems and occurs when bonding between elementary particles (atoms, molecules, forming blocks) becomes higher than a certain threshold value. Thermal fluctuations break the bonds; therefore, the lower the temperature, the higher the degree of connectivity. Because of that amorphous materials have a characteristic threshold temperature termed glass transition temperature (Tg): below Tg amorphous materials are glassy whereas above Tg they are molten.
In a wider sense, the embedding of material in a glassy matrix is also called vitrification. An important application is the vitrification of radioactive waste to obtain a stable compound that is suitable for ultimate disposal.
When sucrose is cooled slowly it results in crystal sugar (or rock candy), but when cooled rapidly it can form syrupy cotton candy (candyfloss).In the process of vitrification the solid waste is exposed to heat and is converted into a sort of glass like substance.
Vitrification can also occur when starting with a liquid such as water, usually through very rapid cooling or the introduction of agents that suppress the formation of ice crystals. This is in contrast to ordinary freezing which results in ice crystal formation. Additives used in cryobiology or produced naturally by organisms living in polar regions are called cryoprotectants.
Arctic frogs and some other ectotherms naturally produce glycerol or glucose in their livers to reduce ice formation. When glucose is used as a cryoprotectant by arctic frogs, massive amounts of glucose are released at low temperature and a special form of insulin allows for this extra glucose to enter the cells. When the frog rewarms during spring, the extra glucose must be rapidly eliminated, but stored. Arctic insects also use sugars as cryoprotectants. Arctic fish use antifreeze proteins, sometimes appended with sugars, as cryoprotectants.
One method of vitrification uses magnetic field to keep water fluent while supercooling it. When the magnetic field is turned off, the water will instantly freeze and ice crystal will not have time to form. The method was developed in Japan to preserve Sushi. Research into using the method for vitrifying organs for organs transplant is currently undergoing using the "Cells Alive System" produced by the Japanese company ABI. It has already proved to be useful for vitrification of teeth 
Ordinary soda-lime glass, used in windows and drinking containers, is created by the addition of sodium carbonate and lime (calcium oxide) to silicon dioxide. Without these additives silicon dioxide will require very high temperature to obtain a melt and subsequently (with slow cooling) a glass.
Vitrification is a proven technique in the disposal and long-term storage of nuclear waste or other hazardous wastes. Waste is mixed with glass-forming chemicals in a melter to form molten glass that then solidifies in canisters, immobilizing the waste. The final waste form resembles obsidian and is a non-leaching, durable material that effectively traps the waste inside. The waste can be stored for relatively long periods in this form without concern for air or groundwater contamination. Bulk vitrification uses electrodes to melt soil and wastes where they lay buried. The hardened waste may then be disinterred with less danger of widespread contamination. According to the Pacific Northwest National Labs, "Vitrification locks dangerous materials into a stable glass form that will last for thousands of years."
Vitrification in cryopreservation is used as a common method to preserve, for example, human egg cells (oocytes) (in oocyte cryopreservation) and embryos (in embryo cryopreservation). For years, glycerol has been used in cryobiology as a cryoprotectant for blood cells and bull sperm, allowing storage at liquid nitrogen temperatures. However, glycerol cannot be used to protect whole organs from damage. Instead, many biotechnology companies are researching the development of other cryoprotectants more suitable for such uses. A successful discovery may eventually make possible the bulk cryogenic storage (or "banking") of transplantable human and xenobiotic organs. A substantial step in that direction has already occurred. Twenty-First Century Medicine has vitrified a rabbit kidney to -135°C with their proprietary vitrification cocktail. Upon rewarming, the kidney was successfully transplanted into a rabbit, with complete functionality and viability, able to sustain the rabbit indefinitely as the sole functioning kidney.
Currently, vitrification techniques have only been applied to brains (neurovitrification) by Alcor and to the upper body by the Cryonics Institute, but research is in progress by both organizations to apply vitrification to the whole body.
See also 
- A.K. Varshneya. Fundamentals of inorganic glasses. Sheffield: Society of Glass Technology, 2006.
- M.I. Ojovan, W.E. Lee. Connectivity and glass transition in disordered oxide systems J. Non-Cryst. Solids, 356, 2534-2540 (2010).
- Kaku M, Kamada H, Kawata T, Koseki H, Abedini S, Kojima S, Motokawa M, Fujita T, Ohtani J, Tsuka N, Matsuda Y, Sunagawa H, Hernandes RA, Ohwada N, Tanne K (2010). "Cryopreservation of periodontal ligament cells with magnetic field for tooth banking". Cryobiology 61 (1): 73–78. doi:10.1016/j.cryobiol.2010.05.003. PMID 20478291.
- M.I. Ojovan, W.E. Lee. Glassy wasteforms for nuclear waste immobilisation. Metallurgical and Materials Transactions A, 42 (4), 837-851 (2011).
- "Waste Form Release Calculations for the 2005 Integrated Disposal Facility Performance Assessment" (PDF). PNNL-15198. Pacific Northwest National Laboratory. July, 2005. Retrieved 2006-11-08.
- Fahy GM, Wowk B, Pagotan R, Chang A, Phan J, Thomson B, Phan L (2009). "Physical and biological aspects of renal vitrification". ORGANOGENESIS 5 (3): 167–175. doi:10.4161/org.5.3.9974. PMC 2781097. PMID 20046680.
- Steven Ashle, Divide and Vitrify, June 2002, Scientific American
- Stefan Lovgren, Corpses Frozen for Future Rebirth by Arizona Company, March 2005, National Geographic
- Vitrification: Putting the Heat on Waste