Tarnopolsky studied composition at the Moscow Conservatory with Nikolai Sidelnikov and Edison Denisov and music theory with Yuri Kholopov. He graduated from the conservatory in 1978, and completed post-graduate studies in 1980. Later he became professor of the Moscow Conservatory.
In 1990 he became a member of ACM - Association for Contemporary Music When the association split in two parts, Tarnopolsky became a leader of a splinter group called CCMM - "Centre for Contemporary Music, Moscow" based on the Moscow Conservatory. He also ran the ensemble "Studio of New Music".
He wrote operas, one symphony, concertos, orchestral works, chamber and vocal music.
- The Three Graces, an opera-parody in three scenes Text: Carl Maria von Weber (1988) 45' premiere: April 30, 1988, Bolshoi Hall of Shostakovich Philharmony, Leningrad, Orchestra and Choir of Culture Ministry USSR, cond. Gennady Rozhdestvensky
- Wenn die Zeit über die Ufer tritt (When Time Overflows From Its Shores, opera in three scenes Text: Ralf Günther Mohnnau after Anton Chekhov's Three Sisters, commissioned for the Munich Biennale,(1999) 90', premiere: April 27, 1999, Münchener Biennale, Staatstheater am Gärtnerplatz, conductor Ekkehard Klemm
- Chevengur for voice and ensemble, text by Andrey Platonov (2001) 13'
- Cinderella theatricalize cantata for children's choir, children's orchestra, 6 narrators and professional ensemble 2003 60' Text: Roald Dahl's "Revolting Rhymes" adapted by Donald Sturrock, premiere: 28 April 2003, Barbican, London, Centre for Young Musicians orchestra and London Schools Symphony Orchestra, conductor Peter Ash
- Feux follets, for orchestra (2003) 10'
- Foucault's Pendulum, for orchestra (2004) 25'
- "Soviet Composer Breathing More Freely in These Days of Perestroika". Los Angeles Times. 9 November 1989. Retrieved 28 December 2010.
- Valeria Tsenova: The "culturology" of Vladimir Tarnopolsky; List of Vladimir Tarnopolsky's principal works in «Ex oriente...II» Nine Composers from the former USSR: Andrei Volkonsky, Sergei Slonimsky, Alemdar Karamanov, Valentin Silvestrov, Nikolai Karetnikov, Roman Ledenyov, Faraj Karaev, Victor Ekimovsky, Vladimir Tarnopolsky (studia slavica musicologica, Bd. 30), Edited by Valeria Tsenova 245 pp., music illus., English Edition. ISBN 3-928864-91-2