Volinanserin

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Volinanserin
MDL-100,907 structure.png
Systematic (IUPAC) name
(R)-(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]-4-piperidyl]methanol
Clinical data
Legal status
?
Identifiers
CAS number 139290-65-6
ATC code None
PubChem CID 5311271
IUPHAR ligand 185
ChemSpider 4470782
UNII EW71EE171J YesY
ChEMBL CHEMBL74355
Chemical data
Formula C22H28FNO3 
Mol. mass 373.46 g/mol

Volinanserin (MDL-100,907) is a highly selective 5-HT2A receptor antagonist. It is widely used in scientific research to investigate the function of the 5-HT2A receptor.[1][2][3] Volinanserin is also being trialed as a potential antipsychotic, antidepressant and treatment for insomnia.[4][5][6]

See also[edit]

References[edit]

  1. ^ Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL (November 1992). "5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine". European Journal of Pharmacology 223 (1): 65–74. doi:10.1016/0014-2999(92)90819-P. PMID 1362159. 
  2. ^ Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F (April 2009). "Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET". Bioorganic & Medicinal Chemistry 17 (8): 2989–3002. doi:10.1016/j.bmc.2009.03.021. PMID 19329329. 
  3. ^ Nic Dhonnchadha BA, Fox RG, Stutz SJ, Rice KC, Cunningham KA (April 2009). "Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model". Behavioral Neuroscience 123 (2): 382–96. doi:10.1037/a0014592. PMID 19331461. 
  4. ^ Offord SJ, Wong DF, Nyberg S (August 1999). "The role of positron emission tomography in the drug development of M100907, a putative antipsychotic with a novel mechanism of action". Journal of Clinical Pharmacology. Suppl: 17S–24S. PMID 10434243. 
  5. ^ Marek GJ, Martin-Ruiz R, Abo A, Artigas F (December 2005). "The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine". Neuropsychopharmacology 30 (12): 2205–15. doi:10.1038/sj.npp.1300762. PMID 15886717. 
  6. ^ Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in Medicinal Chemistry 8 (11): 969–76. doi:10.2174/156802608784936700. PMID 18673166.